血清IMA、Lp-PLA2、cTnI对急性冠状动脉综合征的诊断价值

Diagnostic value of serum IMA,Lp-PLA2 and cTnI in acute coronary syndrome

目的探讨血清缺血修饰蛋白(IMA)、脂蛋白相关磷脂酶A2(Lp-PLA2)、肌钙蛋白I(cTnI)在急性冠状动脉综合征(ACS)中的诊断价值。方法选择138例ACS患者,其中急性心肌梗死(AMI)患者79例、不稳定型心绞痛(UAP)患者59例,以50例健康体检者作为健康对照组,比较各组血清IMA、Lp-PLA2及cTnI水平,并绘制ROC曲线评价各指标在ACS中的诊断价值。结果与健康对照组相比,UAP组和AMI组患者血清IMA、Lp-PLA2及cTnI水平显著升高,差异有统计学意义(t=7.286、8.589、8.952,均P<0.01);与UAP组相比,AMI组患者血清IMA、Lp-PLA2及cTnI水平明显升高,差异有统计学意义(t=4.063、5.987、2.062,均P<0.05)。通过ROC曲线分析,IMA、Lp-PLA2及cTnI在ACS中的曲线下面积(AUC)分别为0.821、0.843、0.852。结论血清IMA、Lp-PLA2、cTnI可用于ACS的监测和早期诊断。

Objective To explore the diagnostic value of serum ischemia‐modified albumin （IMA） ,lipoprotein‐associated phos‐pholipase A2 （Lp‐PLA2） and cardiac troponin I （cTnI） in acute coronary syndrome （ACS） .Methods The levels of serum IMA , Lp‐PLA2 and cTnI were detected in 138 cases of ACS ,including 79 cases of acute myocardial infarction （AMI） ,59 cases of unstable angina pectoris （UAP） ,and the detection results were compared with those in 50 individuals undergoing physical examination（con‐trol group） .The levels of serum IMA ,Lp‐PLA2 and cTnI were compared among various groups .The receiver characteristic curve （ROC） was drawn to evaluate the diagnostic value of IMA ,Lp‐PLA2 and cTnI in ACS .Results The levels of serum IMA ,Lp‐PLA2 and cTnI in patients with UAP and AMI were higher than those in the healthy control group ,and there was statistical differ‐ence between them（t=7 .286 ,8 .589 ,8 .952 ,P〈0 .01） .Comparing with the UAP group ,the levels of serum IMA ,Lp‐PLA2 and cTnI in the AMI group were significantly increased（t=4 .063 ,5 .987 ,2 .062 ,P〈0 .05） .In the ROC curve analysis ,the area under ROC curve （AUC） of IMA ,Lp‐PLA2 and cTnI were 0 .821 ,0 .843 and 0 .852 respectively .Conclusion The levels of serum IMA , Lp‐PLA2 and cTnI can be used for monitoring and early diagnosis of ACS .