幽门螺杆菌感染对冠心病患者相关炎性因子的影响分析

Effect of Helicobacter pylori infection on related inflammatory cytokines in patients with coronary heart disease

目的探讨幽门螺杆菌感染对冠心病患者的血清超敏C-反应蛋白(hs-CRP)、髓过氧化物酶(MPO)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平及病变严重程度的影响,对冠心病的临床诊治研究提供借鉴和参考依据。方法选取2012年12月-2013年12月医院临床诊断为冠心病的患者165例为研究对象,根据患者14 C尿素呼气试验结果将患者分成Hp阳性组和Hp阴性组,分别为82例和83例,对研究对象hs-CRP、MPO、Lp-PLA2、白细胞计数和Gensini积分等指标进行观察和比较,数据采用SPSS 19.0软件进行统计分析。结果 Hp阳性组患者hsCRP、MPO、Lp-PLA2、白细胞计数和Gensini积分分别为(18.34±6.65)mg/L、(250.45±38.45)μg/L、(228.34±49.56)μg/L、(8.29±3.45)109/L和(59.43±5.55)分,均明显高于Hp阴性组,差异有统计学意义(P<0.05)。结论随着冠心病患者幽门螺杆菌感染程度的不断严重,患者血清炎症因子随之升高,患者病情进一步加剧。

OBJECTIVE To investigate the effect of Helicobacter pylori（Hp）infection on the serum high-sensitivity C-reactive protein（hs-CRP）,myeloperoxidase（MPO）,lipoprotein-associated phospholipase A2（Lp-PLA2）level and the severity in patients with coronary heart disease,so as to provide references for clinical diagnosis and treatment of coronary heart disease.METHODS A total of 165 cases of coronary heart disease patients from Dec.2012 to Dec.2013 in our hospital were chosen as the research objects.According to the 14 C urea breath test results,patients were divided into Hp positive group（82cases）and Hp negative group（83cases）.The hs-CRP,MPO,Lp-PLA2,white blood cell count and Gensini scores and other indicators for the objects were observed and compared.The data were analyzed by SPSS 19.0.RESULTS The hs-CRP,MPO,Lp-PLA2,white blood cell count and Gensini score of patients in Hp positive group were（18.34±6.65）mg/L,（250.45±38.45）μg/L,（228.34±49.56）μg/L,（8.29 ± 3.45）109/L and（59.43±5.55）points,which were significantly higher than patients in Hp negative group（P〈0.05）.CONCLUSION With the extent of Hp infection in patients with coronary artery disease,the patients serum inflammatory factors will rise,and the patients＇ conditions will be further intensified.