依达拉奉对病毒性脑炎患者血清蛋白代谢及脑脊液相关指标的影响研究

Influence of edaravone on serum protein metabolism and cerebrospinal fluid in patients with viral encephalitis

目的探讨依达拉奉对病毒性脑炎患者血清蛋白代谢及脑脊液相关指标的影响,为其临床研究提供参考依据。方法选择2013年3月-2015年10月120例病毒性脑炎患者作为研究对象,采用随机数字表法分为观察组与对照组各60例,对照组患者给予常规抗病毒治疗,观察组患者在常规治疗基础上给予依达拉奉,两周后比较两组患者疗效,数据采用SPSS 17.0软件进行统计分析。结果观察组患者治疗总有效率为98.3%,明显高于对照组的88.3%,差异有统计学意义(P<0.05);观察组患者头痛消失时间(4.43±1.51)d、呕吐消失时间(2.72±1.09)d、意识好转时间(5.13±1.76)d,均明显低于对照组患者,差异有统计学意义(P<0.05)。结论病毒性脑炎患者抗病毒联合依达拉奉可以明显提高临床疗效,有效降低脑损伤,改善脑功能,促进患者病情恢复。

OBJECTIVE To analyze the influence of edaravone on serum protein metabolism and cerebrospinal fluid in patients with viral encephalitis,so as to provide references for clinical researches.METHODS A total of 120 patients with viral encephalitis from Mar.2013 to Oct.2015 were selected,and divided into observation group and control group by random number table method,with 60 cases in each group.Patients in control group were given conventional antiviral therapy,and patients in observation group were also given edaravone treatment.The differences of serum protein metabolism and cerebrospinal fluid were compared two weeks later.The data were analyzed by SPSS 17.0.RESULTS The total effective rate in observation group was 98.3%,which was higher than 88.3%in control group.The difference was significant（P〈0.05）.The headaches disappear time,vomiting disappear time and consciousness turnaround time in observation group were（4.43±1.51）d,（2.72±1.09）d,and（5.13±1.76）d,respectively,which were lower than those in control group.The differences were significant（P〈0.05）.CONCLUSION Antiviral treatment combined edaravone can obviously improve the clinical curative effect,effectively reduce the brain injury,improve brain function,and promote patients recover in patients with viral encephalitis.