肾小球肾炎患者血清自由基与免疫指标检测的临床分析

Clinical analysis of serum levels of free radicals and immune index detection in APSGN patients

目的探讨链球菌感染后肾小球肾炎(APSGN)患者血清超氧化物歧化酶(SOD)、一氧化氮(NO)、一氧化氮合酶(NOS)、白介素和T淋巴细胞亚群变化,为临床治疗APSGN提供参考依据。方法选取2014年1月-2015年10月在医院就诊的50例APSGN患者为感染组,同期门诊健康体检人员50名为对照组,检测血清指标水平,数据采用SPSS 19.0软件进行统计分析。结果感染组SOD、NO为(216.29±98.66)(52.50±9.91)ng/ml,低于对照组(263.84±83.25)(58.04±10.92)ng/ml,感染组NOS为(1.62±0.82)μg/ml,高于对照组(1.23±0.63)μg/ml;感染组IL-10、IL-17为(44.20±10.33)μg/L、(19.95±6.88)ng/L,高于对照组(24.02±8.57)μg/L、(11.92±7.24)ng/L,两组比较差异均有统计学意义(P<0.05)。结论 APSGN患者血清SOD、NO较正常人群有所降低,NOS、IL-10、IL-17有所升高,同时T淋巴细胞紊乱,检测以上指标可有助于了解患者病情变化及进行辅助诊断。

OBJECTIVE To explore the changes of post-streptococcal glomerulonephritis（APSGN）in patients with serum superoxide dismutase（SOD）,nitric oxide（NO）and nitric oxide synthase（NOS）,interleukin,and T lymphocyte subsets,and provide references for clinical treatment in APSGN.METHODS A total of 50 patients with APSGN from Jan.2014 to Oct 2014 in hospital were collected as infection group,and over the same period,50 cases of normal people according to clinic health physical examination were selected as control group,and the following indicators were tested：the serum SOD,NO,NOS and interleukin 10（IL-10）and 17（IL-17）.The results were statistically analyzed by software SPSS 19.0.RESULTS SOD and NO of infection group were（216.29±98.66）ng/ml and（52.50±9.91）ng/ml,lower than those of control group,which were（263.84±83.25）ng/ml,（58.04±10.92）ng/ml;the NOS of the infection group was（1.62±0.82）μg/ml,higher than（1.23±0.63）μg/ml of the control group.IL-10 and IL-17 of infection group were（44.20±10.33）μg/L,（19.95±6.88）ng/L,higher than（24.02±8.57）μg/L,（11.92±7.24）ng/L in control group.The above data comparing differences between two groups had significant differences（P〈0.05）.CONCLUSION APSGN serum SOD and NO in patients with a normal population decreases,NOS,IL-10,IL-17 increases,and T lymphocyte disorders at the same time,testinf the above indicators can help corresponding the patient′s condition changes and having auxiliary diagnosis.