胆道感染患者血清瘦素与可溶性瘦素受体和血脂水平变化的相关性研究

Correlation between the changes of serum Lep,sLR and blood lipid levels in biliary tract infection patients

目的探讨胆道感染患者血清瘦素(Lep)、可溶性瘦素受体(sLR)与血脂水平变化及相关性,为胆囊感染的临床治疗提供参考依据。方法选取2015年1-8月于医院收治100例胆道感染患者为胆道感染组,同期门诊行健康体检的健康人群50名为对照组,比较两组受试人员血清Lep、sLR及血脂水平,数据采用SPSS 19.0软件进行统计分析。结果胆道感染组患者Lep、TG、低密度脂蛋白(LDL-C)、总胆固醇(TC)水平分别为(65.30±10.91)ng/μl、(1.73±0.97)mmol/L、(3.40±1.12)mmol/L、(4.09±0.47)mmol/L,均高于对照组,两组比较差异有统计学意义(P<0.05)。结论胆道感染患者血清Lep及血脂明显升高、sLR下降,Lep与血脂升高有密切相关性,Lep升高可能是引起胆道感染患者血脂紊乱的原因之一。

OBJECTIVE To discuss correlation between the changes of serum Leptin（Lep）,soluble leptin receptor（sLR）and blood lipid levels in biliary tract infection patients,so as to provide reference for clinical treatment of gallbladder infection.METHODS A total of 100 patients with biliary tract infection from Jan.to Aug.2015 treated in the hospital were selected as biliary infection group,another 50 healthy people in outpatient health examination as control group.Lep,sLR and blood lipid levels were compared in two groups,and the data were analyzed by SPSS 19.0.RESULTS The levels of Lep,triglyceride（TG）,low density lipoprotein（LDL-C）and total cholesterol（TC）were（65.30±10.91）ng/μL,（1.73±0.97）mmol/L,（3.40±1.12）mmol/L and（4.09±0.47）mmol/L in biliary infection group,which were higher than those in control group（P〈0.05）.CONCLUSIONSerum Lep and blood lipid increase significantly but SLR decreases obviously in the biliary infection group patients.Lep has close correlation with elevated blood lipids,and Lep rise is likely to be one of the causes of dyslipidemia in patients with biliary tract infection.