二期翻修术对全髋关节置换术后患者感染相关指标的影响观察

Influence of two-stage rivision for the infection related indexes of patients with infections after replacement of total hip

目的观察二期翻修术对全髋关节置换术后感染患者相关指标的影响,为治疗方式的选取提供参考依据。方法选取2012年2月~2015年7月医院收治的42例全髋关节置换术后感染患者为研究对象,将其根据手术时机分为对照组（一期翻修术组）21例和观察组（二期翻修术组）21例,比较两组患者炎性因子,数据采用SPSS15.0软件进行统计分析。结果治疗前两组患者炎性因子及其他感染指标差异均无统计学意义,术后1、3d及7d观察组炎性因子中白细胞介素（IL）-1β、IL-4、IL-6及IL-10水平均低于对照组,观察组其他炎性因子及其他常见感染指标也均低于对照组,差异均有统计学意义（P〈0.05）。结论二期翻修术对全髋关节置换术后感染患者感染相关指标的不良影响小于一期翻修术,因此更为适用于全髋关节置换术后感染患者。

OBJECTIVE To observe the influence of two-stage rivision for the infections related indexes of patients with infection after replacement of total hip,in order to provide evidence for the treatment methods selection.METHODS A total of 42 patients with infections after replacement of total hip in our hospital from Feb.2012 to Jul.2015 were selected as the study objects,and they were divided into control group（one-stage rivision group,21cases）and observation group（two-stage rivision group,21cases）according to the operation opportunity,then the inflammatory factors of two groups were compared.SPSS 15.0was used for statistic analysis.RESULTS The inflammatory factors and other common infection indexes of two groups before the treatment had no significant differences.The interleukins including IL-1β,IL-4,IL-6and IL-10 of observation group at 1st,3rd and 7th day after the operation were all lower than those in control group,and the other inflammatory indexes and other common inflammatory indexes were all lower than those in control group（P〈0.05）.CONCLUSION The bad influence of two-stage rivision for the infections related indexes of patients with infections after replacement of total hip is smaller than the influence in one-stage rivision,so it is more suitable to the patients with infections after replacement of total hip.