女性外阴尖锐湿疣患者人乳头状瘤病毒感染类型与复发的临床分析

Infection types and recurrence clinical analysis on the female genital condyloma acuminatum with human papilloma virus infection

目的探讨女性外阴尖锐湿疣人乳头状瘤病毒(HPV)感染的不同类型以及其与临床复发的关系,为临床上治疗女性外阴尖锐湿疣HPV感染提供参考依据。方法选取2014年5月-2015年7月于医院接受治疗的确诊为外阴尖锐湿疣HPV感染的女性患者146例为研究对象,对患者于治疗后3个月和6个月进行随访,观察患者的复发率,数据采用SPSS 16.0软件进行统计分析。结果低危型HPV感染87例占59.59%,高危型HPV感染59例占40.41%;单一型感染患者94例占64.38%,以低危型HPV为主,双重感染患者23例占15.75%,以双、三重感染为多见,占26.71%;外阴尖锐湿疣患者治疗后3个月复发率,低危型为20.69%、高危型为6.78%;治疗后6个月复发率,低危型为1.15%、高危型为27.12%,以上数据差异均有统计学意义(P<0.05)。结论女性外阴尖锐湿疣HPV感染的不同类型决定了患者的复发情况不同,临床上应当根据患者不同的感染类型来给予合理的防治措施。

OBJECTIVE To explore the different types of female genital condyloma acuminatum HPV infection and its relationship with clinical recurrence,so as to provide theoretical guidance and basis for the clinical treatment of female genital condyloma acuminatum HPV infection.METHODS A total of 146 women receiving treatment in hospital and diagnosed with genital condyloma acuminatum HPV infection from May 2014 to Jul.2015 were selected.Patients had three-month and six-month follow-up treatment.The recurrence rates were observed and analyzed by SPSS 16.0software.RESULTS The number of low-risk HPV infection was 87,accounting for 59.59%,and high-risk HPV infection was 59,accounting for 40.41%.The types of HPV infection statistics showed that94 patients were in single type of infection,accounting for 64.38%,mainly with low-risk HPV,23 cases were in dual-infected patients,accounting for 15.75%,and double and triple infection were more common,accounting for26.71%.The recurrence rate in patients with genital condyloma acuminatum after 3 months treatment was20.69%in type of low-risk,6.78%in high-risk.After 6months treatment,low-risk recurrence rate was 1.15%,and high-risk was 27.12%.The above data had significant differences（P〈0.05）.CONCLUSIONThe types of female genital condyloma acuminatum HPV infection determines recurrence situation,so the reasonable preventive and treatment measures should be given according to different types of infection in patients in clinic.