肠道病毒71型手足口病患儿血清TGFβ及白细胞介素水平变化分析

Changes of serum TGF-β and interleukins in patients with hand-foot-mouth disease induced by EV71

目的研究肠道病毒71型(EV71型)手足口病患儿血清TGFβ及白细胞介素水平变化,为相关临床治疗提供参考依据。方法对医院2011年5月-2014年5月诊治EV71感染手足口病患儿50例进行分析,分为普通病例组和重症病例组,各25例,同期选取健康体检儿童20名为对照组;比较3组受试儿童临床血清炎症因子白细胞介素(IL)-1、IL-2、IL-6、IL-10、转化生长因子-β(TGF-β)、肿瘤坏死因子-α(TNF-α)及核因子kappa-B(NFkB)和高敏C-反应蛋白(hs-CRP)水平,数据采用SPSS 19.0软件进行统计分析。结果与对照组相比,手足口病患儿血清炎症因子IL-1、IL-2、IL-6、IL-10、TGFβ、TNFα及NFκB和hs-CRP水平明显升高,且与对照组比较差异有统计学意义(P<0.05);重症病例组上述炎症因子水平明显高于普通病例组,且两组之间差异有统计学意义(P<0.05)。结论炎症因子水平异常参与了EV71感染手足口病患儿的发病过程,且其浓度随患者疾病的严重性增加而升高。

OBJECTIVE To investigate the changes of serum TGF-βand interleukins（IL）in patients with hand-footmouth disease（HFMD）induced by EV71,so as to provide references for clinical treatment.METHODS A total of50 cases of HFMD patients in our hospital from May 2011 to May 2014 were enrolled in this research.They were divided into normal case group and severe case group,with 25 cases in each group.Another 20 cases of healthy children were selected as control group.The serum IL-1,IL-2,IL-6,Il-10,transcription growth factor-β（TGF-β）,tumor necrosis factor-α（TNF-α）,nuclear factor-κB（NF-κB）and C reactive protein（hs-CRP）levels of the three groups were detected and compared.The data were analyzed by SPSS 19.0.RESULTS The serum IL-1,IL2,IL6,IL10,TGF-β,TNF-α,NF-κB and hs-CRP levels of HFMD patients were higher than those of control group（P〈0.05）.The above inflammatory factors of severe case group were significantly higher than those of normal case group（P〈0.05）.CONCLUSIONAbnormal inflammatory factors were enrolled in the pathogenesis of HFMD and have a close relationship with the severity of HFMD.