摘要
目的:探索重复经颅磁刺激(repetitive transcranial magnetic stimulation,r TMS)治疗氯胺酮心理渴求的疗效,以及产生疗效的神经学机制。方法:10名有氯胺酮心理渴求者采用视觉模拟渴求评分(Visual Analogue Scale,VAS)评估心理渴求后进行r TMS治疗,治疗位点为右侧前额叶背外侧皮质,刺激频率15Hz,共10次。治疗结束后对比分析治疗前后患者脑功能活动的静息态功能磁共振(resting-state f MRI)局部一致性(Regional Homogeneity,Re Ho)变化情况。结果:与治疗前相比,治疗后氯胺酮心理渴求者视觉模拟渴求评分(VAS)显著下降(P=0.002);静息态功能分析发现左额叶中上回Re Ho信号减低,右内侧额上回和右扣带回的ReHo增强(P<0.05,Alpha Sim校正,cluster size=85)。结论:本研究提示rTMS治疗氯胺酮渴求具有潜在疗效,涉及的神经学机制可能与额叶-边缘系统的相关回路有关。
Objective： To explore the effects of repetitive transcranial magnetic stimulation（ rTMS） for the treatment of ketamine craving and the neural mechanism. Methods： Ketamine dependent patients（ n = 10） were treated with rTMS directed to right dorsolateral frontal cortex. Drug craving scores were evaluated by a visual analogue scale. Resting-state fMRI was scanned before and after the treatment,then regional homogeneity（ ReHo） was employed to analyze alterations of the functional brain activities. Results： After 10 sessions of r TMS treatment,the ketamine craving scores decreased significantly（ P = 0. 002）; Re Ho signal decreased statistically in left superior middle frontal gyrus and increased in right medial frontal gyrus and cingulated gyrus.（ P 0. 05,Alpha Sim correction,cluster size = 85）. Conclusion： This study suggested the potential effectiveness of rTMS on ketamine craving and the frontal-limbic circuit might be involved in the neural mechanism.
出处
《中国药物滥用防治杂志》
CAS
2016年第4期187-190,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
2013广州市科信局科技计划项目
编号:2013J4100097
2014广州市科信局科技计划项目
编号:2014J4100137
关键词
重复经颅磁刺激
氯胺酮
药物渴求
局部一致性
repetitive transcranial magnetic stimulation
ketamine
drug craving
regional homogeneity
