摘要
目的探讨免疫球蛋白样转录子4(ILT4)与Ki67在上皮性卵巢癌淋巴结转移患者中的表达情况。方法回顾性分析70例上皮性卵巢癌患者,通过淋巴结转移情况分为淋巴结转移组(37例)和无淋巴结转移组(33例),观察两组患者ILT4、Ki67的表达情况。结果免疫组织化学结果显示,淋巴结转移组中,卵巢癌组织中ILT4表达水平低于无淋巴结转移组,Ki67表达水平高于无淋巴结转移组(P﹤0.05);淋巴结转移组ILT4阳性率35.14%(13/37)低于无淋巴结转移组的84.85%(28/33),差异有统计学意义(P﹤0.05);淋巴结转移组Ki67阳性率表达81.08%(30/37)高于无淋巴结转移组的45.45%(15/33),差异有统计学意义(P﹤0.05)。结论在上皮性卵巢癌淋巴结转移患者中,ILT4水平表达降低,Ki67表达升高,可将其作为诊断病情的指标。
Objective To investigate the expression profile of ILT4 and Ki67 in patients with epithelial ovarian carci-noma and lymph node metastasis. Method A retrospective analysis was performed in 70 patients with epithelial ovarian cancer, who were stratified as lymph node metastasis group （n=37） and non-lymph node metastasis group （n=33） by re-spective status of metastasis. The expression of ILT4 and Ki67 in both groups were analyzed. Result In immunohisto-chemical analysis, the expression of ILT4 in ovarian cancer tissue of metastasis group was lower than that in non-metasta-sis group, while the expression of Ki67 was higher in the former than that in the latter （P〈0.05）;the positive rate of ILT4 expression in metastasis group was 35.14%（13/37）, lower than that in non-metastasis group at 84.85%（28/33）, with sig-nificant difference observed （P〈0.05）; while the positive rate of Ki67 was 81.08% （30/37） in metastasis group, higher than that in non-metastasis group at 45.45%（15/33）, which was of significant difference （P〈0.05）. Conclusion In epitheli-al ovarian cancer patients with lymph node metastasis, it is common that low ILT4 expression is accompanied by high ex-pression of Ki67, which can be used as an important index for the diagnosis.
出处
《癌症进展》
2016年第6期591-593,共3页
Oncology Progress
