急诊应用胺碘酮治疗快速型心律失常的疗效及安全性研究

Safety and efficacy of amiodarone in emergency applications to tachyarrhythmia

目的探讨急诊应用胺碘酮治疗快速型心律失常的疗效及安全性。方法将来自2013年1月至2015年11月的90例快速型心律失常患者分为实验组(45例)和对照组(45例),实验组采用胺碘酮治疗,而对照组采用普罗帕酮治疗,统计两组的疗效,心率、Q-T间期、P-R间期和不良反应,采用卡方检验和t检验分析相关数据。结果实验组总有效率明显高于对照组(P<0.05);治疗后,两组心率均明显下降,Q-T间期、P-R间期均明显延长,但实验组心率下降的幅度明显大于对照组(P<0.05);两组的不良事件发生率差异无统计学意义(P>0.05)。结论急诊应用胺碘酮治疗快速型心律失常的疗效明确,不良反应发生率低,值得推荐。

Objective To investigate the safety and efficacy of amiodarone in emergency applications to tachyarrhythmia. Methods The tachyarrhythmia patients were received and cured from January 2013 to November 2015,which were divided into experimental group（ 45 cases） and control group（ 45 cases）.Experimental group were treated with amiodarone,and the control group were treated with propafenone. The curative effect,heart rate,Q-T interval,P-R interval and adverse reaction of the two groups were statistical. Chisquare test and t test were used to analyze the data. Results The total effective rate of the experimental group were significantly higher than control group（ P〈0. 05）. The post-treatment heart rate of two groups were all obviously decreased,the post-treatment Q-T interval and P-R interval of two groups were all obviously prolonged,and heart rate decreased range of experimental group significantly larger than control group（ P〈0. 05）. The incidence rate of adverse reaction in the two groups had no significant（ P〉0. 05）. Conclusions The curative effect of amiodarone in emergency applications to tachyarrhythmia is clear-cut,and the incidence rate of adverse reaction is low too,so it is worthy of promotion.