阿替普酶在急性脑梗死治疗中的应用效果分析

Analysis of application effect by alteplase in the treatment of acute cerebral infarction

目的综合分析阿替普酶在急性脑梗死治疗中的应用效果。方法 50例急性脑梗死患者,随机分为观察组与对照组,各25例。观察组采用阿替普酶静脉溶栓治疗,对照组采用非静脉溶栓治疗。比较两组的治疗效果。结果观察组总有效率92.0%高于对照组68.0%,差异具有统计学意义(P<0.05);治疗后5 h、22 h、12 d观察组美国国立卫生院神经功能缺损评分(NIHSS)(11.2±4.5)、(8.4±3.6)、(4.6±2.1)分显著优于对照组(14.9±4.4)、(12.1±3.7)、(10.1±2.3)分,差异具有统计学意义(P<0.05)。结论采用阿替普酶静脉溶栓治疗急性脑梗死患者相比采用非静脉溶栓治疗效果更理想。

Objective To comprehensively analyze application effect by alteplase in the treatment of acute cerebral infarction.Methods A total of 50 acute cerebral infarction patients were randomly divided into observation group and control group, with 25 cases in each group. The observation group received alteplase for intravenous thrombolytic treatment, and the control group received no intravenous thrombolytic treatment. Curative effects were compared between the two groups.Results The observation group had higher total effective rate as 92.0% than 68.0% of the control group, and the difference had statistical significance （P〈0.05）. In 5 h, 22 h and 12 d after treatment, the observation group had much better national institutes of health stroke scale （NIHSS） scores as （11.2±4.5）, （8.4±3.6） and （4.6±2.1） points than （14.9±4.4）, （12.1±3.7） and （10.1±2.3） points in the control group, and the difference had statistical significance （P〈0.05）.Conclusion Implement of alteplase for intravenous thrombolytic treatment provides more ideal effect in treating acute cerebral infarction patients than non-intravenous thrombolytic treatment.