摘要
目的:探讨5-氨基酮戊酸光动力疗法(ALA-PDT)联合胸腺五肽对复发性尖锐湿疣患者外周血IL-17、IL-23表达的影响及其作用机制。方法140例复发性尖锐湿疣患者采用随机数字表法分为观察组53例、对照1组42例和对照2组45例,观察组采用 ALA-PDT 联合胸腺五肽治疗,对照1组采用 ALA-PDT 治疗,对照2组采用胸腺五肽治疗,另选择24例健康体检者作为健康组,采用酶联免疫吸附法(ELISA)测定复发性尖锐湿疣患者治疗前、后和健康体检者外周血中 IL-17、IL-23水平。结果复发性尖锐湿疣患者血清IL-17、IL-23水平高于健康组(t =28.10,P <0.01;t =11.10,P <0.01),治疗后观察组 IL-17、IL-23水平较治疗前明显降低,差异有统计学意义(t =61.17,P <0.01;t =28.02,P <0.01)。结论 ALA-PDT 联合胸腺五肽治疗复发性尖锐湿疣患者抑制了 IL-17、IL-23的表达,从而达到治疗作用。
Objective To explore effect of 5 -aminolevulinic acid -photodynamic therapy combined with thymopentin -5 on IL -17,IL -23 expression of recurrent condylomata acuminata patients.Methods 140 patients with recurrent condylomata acuminata were randomly divided into 3 groups.53 cases in observation group were treated by 5 -aminolevulinic acid -photodynamic therapy combined with thymopentin -5,42 cases in control group 1 were treated by 5 -aminolevulinic acid -photodynamic therapy,and 45 cases in control group 2 were treated by thymopen-tin -5.24 healthy subjects were served as normal controls.IL -17,IL -23 levels were determined by enzyme linked immunosorbent assay before and after the clinical therapy.Results IL -17,IL -23 levels in the patients with recur-rent condylomata acuminata were significantly lower than those in healthy subjects(t =28.10,P 〈0.01;t =11.10, P 〈0.01).There were significant differences in IL -17,IL -23 between recurrent condylomata acuminata patients and healthy persons before treatment.There was significant difference after treatment(t =61.17,P 〈0.01;t =28.02, P 〈0.01).Conclusion 5 -aminolevulinic acid -photodynamic therapy combined with thymopentin -5 in the treat-ment of recurrent condylomata acuminata inhibited IL -17,IL -23 expression,so as to achieve therapeutic effect.
出处
《中国基层医药》
CAS
2016年第16期2530-2533,共4页
Chinese Journal of Primary Medicine and Pharmacy