5-氨基酮戊酸光动力疗法联合胸腺五肽对复发性尖锐湿疣患者外周血白细胞介素-17、白细胞介素-23的影响

Effect of 5 -aminolevulinic acid -photodynamic therapy combined with thymopentin -5 on IL -17,IL -23 expression of recurrent condylomata acuminata patients

目的：探讨5-氨基酮戊酸光动力疗法（ALA-PDT）联合胸腺五肽对复发性尖锐湿疣患者外周血IL-17、IL-23表达的影响及其作用机制。方法140例复发性尖锐湿疣患者采用随机数字表法分为观察组53例、对照1组42例和对照2组45例，观察组采用 ALA-PDT 联合胸腺五肽治疗，对照1组采用 ALA-PDT 治疗，对照2组采用胸腺五肽治疗，另选择24例健康体检者作为健康组，采用酶联免疫吸附法（ELISA）测定复发性尖锐湿疣患者治疗前、后和健康体检者外周血中 IL-17、IL-23水平。结果复发性尖锐湿疣患者血清IL-17、IL-23水平高于健康组（t ＝28．10，P ＜0．01；t ＝11．10，P ＜0．01），治疗后观察组 IL-17、IL-23水平较治疗前明显降低，差异有统计学意义（t ＝61．17，P ＜0．01；t ＝28．02，P ＜0．01）。结论 ALA-PDT 联合胸腺五肽治疗复发性尖锐湿疣患者抑制了 IL-17、IL-23的表达，从而达到治疗作用。

Objective To explore effect of 5 -aminolevulinic acid -photodynamic therapy combined with thymopentin -5 on IL -17,IL -23 expression of recurrent condylomata acuminata patients.Methods 140 patients with recurrent condylomata acuminata were randomly divided into 3 groups.53 cases in observation group were treated by 5 -aminolevulinic acid -photodynamic therapy combined with thymopentin -5,42 cases in control group 1 were treated by 5 -aminolevulinic acid -photodynamic therapy,and 45 cases in control group 2 were treated by thymopen-tin -5.24 healthy subjects were served as normal controls.IL -17,IL -23 levels were determined by enzyme linked immunosorbent assay before and after the clinical therapy.Results IL -17,IL -23 levels in the patients with recur-rent condylomata acuminata were significantly lower than those in healthy subjects（t =28.10,P 〈0.01;t =11.10, P 〈0.01）.There were significant differences in IL -17,IL -23 between recurrent condylomata acuminata patients and healthy persons before treatment.There was significant difference after treatment（t =61.17,P 〈0.01;t =28.02, P 〈0.01）.Conclusion 5 -aminolevulinic acid -photodynamic therapy combined with thymopentin -5 in the treat-ment of recurrent condylomata acuminata inhibited IL -17,IL -23 expression,so as to achieve therapeutic effect.