CD4＋CD25＋Foxp3＋调节性 T 细胞在再生障碍性贫血患者中的临床意义

Clinical significance of CD4＋CD25＋Foxp3＋ regulatory T cells in patients with aplastic anemia

获得性再生障碍性贫血（AA）是由自身反应性 T 细胞介导的骨髓衰竭性疾病，调节性 T 细胞是一类具有免疫抑制性和免疫无能性的 T 细胞亚群，对自身反应性 T 细胞的发生和发展起关键作用，其中最重要的是 CD4＋CD25＋调节性 T 细胞，在自身免疫耐受和维持机体内环境稳定中至关重要，而转录因子 Foxp3是 CD4＋CD25＋调节性 T 细胞发育和发挥免疫功能的关键。近年来发现 AA 患者中存在CD4＋CD25＋Foxp3＋调节性 T 细胞数量和功能的异常，CD4＋CD25＋Foxp3＋调节性 T 细胞在 AA 发生发展中的作用及机制成为当前研究的热点，其在 AA 患者中的临床意义也日趋重要。

Acquired aplastic anemia（AA） is a disease of bone marrow failure mediated by autoimmune T cells. CD4＋CD25＋ regulatory T cells, which have immunosuppressive and anergic, belong to a subpopulation of T cells specialized for immune regulation and play important roles in the development of autoimmune T cells. Foxp3 plays a significant role in the development and function of regulatory T cells which have been confirmed by many investigations. In recent years, the relationship between CD4 ＋CD25 ＋Foxp3 ＋ regulatory T cells and AA has become a hot spot of research. What’s more, its clinical significance is becoming more and more obvious in AA.