小牛血清去蛋白联合替罗非班治疗进展性脑梗死的疗效观察

Clinical observation of deproteinised calf combined with tirofiban in treatment of progressive cerebral infarction

目的研究小牛血清去蛋白联合替罗非班治疗进展性脑梗死的临床疗效。方法选取2014年11月—2015年11月自贡市第一人民医院神经内科收治的进展性脑梗死患者110例,随机分为对照组和治疗组,每组各55例。对照组静脉泵入盐酸替罗非班氯化钠注射液,前30 min速率设定为0.4μg/(kg·min),此后0.1μg/(kg·min)持续泵入。治疗组在对照组治疗基础上静脉滴注小牛血清去蛋白注射液,30 m L加入250 m L生理盐水中,1次/d。两组均连续治疗7 d。观察两组的临床疗效,同时比较两组治疗前后神经功能缺损(NIHSS)评分、Barthel指数的变化情况。结果治疗后,对照组和治疗组的总有效率分别为81.82%、96.36%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者NIHSS评分显著降低,Barthel指数明显升高,同组治疗前后差异均有统计学意义(P<0.05),且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论小牛血清去蛋白联合替罗非班治疗进展性脑梗死具有较好的临床疗效,可改善患者的神经功能损伤程度,提高患者的生活质量,具有一定的临床推广应用价值。

Objective To investigate the effect of deproteinised calf combined with tirofiban in treatment of progressive cerebral infarction. Methods Patients（110 cases） with progressive cerebral infarction in Department of Neurology of Zigong First People＇s Hospital from November 2014 to November 2015 were randomly divided into control and treatment groups. Each group had 55 cases. The patients in the control group were iv pumping with Tirofiban Hydrochloride Sodium Chloride Injection, and the rate was set for 0.4 μg/（kg·min） before 30 min, than 0.1 μg/（kg·min） continuous pumping. The patients in the treatment group were iv administered with Deproteinised Calf Blood Serum Injection on the basis of the control group, 30 m L added into normal saline 250 m L, once daily. The patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and the changes of NIHSS scores and Barthel index in two groups before and after treatment were compared. Results After treatment, the total efficacies in the control and treatment groups were 81.82% and 96.36%, respectively, and there were differences between two groups（P〈0.05）. After treatment, NIHSS scores in two groups were significantly decreased, and Barthel index was significantly increased, the difference was statistically significant in the same group（P〈0.05）. After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. Results Deproteinised calf combined with tirofiban has clinical curative effect in treatment of progressive cerebral infarction, and can improve the nerve function damage degree, also can improve the life quality, which has a certain clinical application value.