聚乙二醇电解质散剂联合乳果糖口服液治疗老年性便秘的疗效观察

Clinical observation of Polyethylene Glycol Electrolytes Powder combined with Lactulose Oral Solution in treatment of senile constipation

目的探讨复方聚乙二醇电解质散(IV)联合乳果糖口服溶液治疗老年性便秘的临床疗效。方法选取2010年12月—2016年1月内江市第一人民医院收治的老年性便秘患者82例,随机分为对照组和治疗组,每组各41例。对照组口服乳果糖口服溶液,15 m L/次,2次/d。治疗组在对照组治疗基础上口服复方聚乙二醇电解质散(IV),取本品A、B两剂各一包,同溶于125 m L温水中成溶液,开始时1次/d,必要时2次/d,或遵医嘱。两组均连续治疗4周。观察两组的临床疗效,同时比较两组治疗前后症状积分的变化情况。结果治疗后,对照组和治疗组的总有效率分别为87.80%、95.12%,两组比较差异有统计学意义(P<0.05)。治疗后,两组患者排便程度评分、粪便性状评分、排便时间评分均显著降低,同组治疗前后差异有统计学意义(P<0.05),且治疗组这些评分的降低程度优于对照组,两组比较差异具有统计学意义(P<0.05)。结论复方聚乙二醇电解质散(IV)联合乳果糖口服溶液治疗老年性便秘具有较好的临床疗效,可明显改善临床症状,安全性较为可靠,具有一定的临床推广应用价值。

Objective To investigate the effect of Polyethylene Glycol Electrolytes Powder combined with Lactulose Oral Solution in treatment of senile constipation. Methods Patients（82 cases） with asthmatic diseases in the First People＇s Hospital of Neijiang from December 2010 to January 2016 were randomly divided into control and treatment groups. Each group had 41 cases. The patients in the control group were po administered with Lactulose Oral Solution, 15 m L/time, twice daily. The patients in the treatment group were po administered with Polyethylene Glycol Electrolytes Powder（IV） on the basis of the control group, a pack of each product A and B dissolved in warm water 125 m L, once daily at the beginning, if necessary, twice daily or as directed by physician. The patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies were evaluated, and the changes of symptom score in two groups before and after treatment were compared. Results After treatment, the total efficacies in the control and treatment groups were 87.80% and 95.12%, respectively, and there were differences between two groups（P〈0.05）. After treatment, scores of defecation degree, fecal character, and defecation time in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. After treatment, the decreased degrees of scores in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. Conclusion Polyethylene Glycol Electrolytes Powder（IV） combined with Lactulose Oral Solution has clinical curative effect in treatment of senile constipation, and can obviously improve the clinical symptoms, and security is more reliable, which has a certain clinical application value.