促性腺激素释放激素在生殖衰老和全身衰老中的变化
摘要
衰老在生物体中广泛存在,是机体组织、器官发生时间依赖性的功能退化的过程。近年的研究发现,下丘脑作为神经-内分泌调节中的关键结构,在衰老过程中发挥统领性的作用,而促性腺激素释放激素(GnRH)在这一过程中也占有一席之地。
出处
《中华医学杂志》
CAS
CSCD
北大核心
2016年第31期2519-2521,共3页
National Medical Journal of China
参考文献25
-
1Guarente L. Aging research-where do we stand and where are we going? [J]. Cell, 2014, 159(1): 15-19. DOI: 10.1016/j. cell. 2014.08. 041.
-
2Zhang G, Li J, Purkayastha S, et al. Hypothalamic programming of systemic ageing involving IKK-13, NF-KB and GnRH [ J ]. Nature, 2013, 497 (7448) : 211-216. DOI : 10. 1038/nature12143.
-
3Wang L, Chadwick W, Park SS, et al. Gonadotropin-releasing hormone receptor system: modulatory role in aging and neurodegeneration[ J. CNS Neural Disord Drug Targets, 2010, 9 (5) : 651-660. DOI : 10. 2174/187152710793361559.
-
4Cheung LW, Wong AS. Gonadotropin-releasing hormone: GnRH receptor signaling in extrapituitary tissues [ J]. FEBS J, 2008, 275 ( 22 ) : 5479-5495. DOI: 10. llll/j. 1742-4658. 2008. 06677. x.
-
5Millar RP, Lu ZL, Pawson AJ, et al. Gonadotropin-releasing hormone receptors[ J]. Endoer Rev, 2004, 25 (2) : 235-275. DOI: 10. 1210/er. 2003-0002.
-
6Kermath BA, Gore AC. Neuroendocrine control of the transition to reproductive senescence: lessons learned from the female rodent model[J]. Neuroendocrinology, 2012, 96(1): 1-12. DOI: 10. 1159/000335994.
-
7Shaw ND, Srouji SS, Histed SN, et al. Aging attenuates the pituitary response to gonadotropin-releasing hormone [ J ]. J Clin Endocrinol Metab, 2009, 94 (9) : 3259-3264. DOI: 10. 1210/ jc. 2009-0526.
-
8Gill S, Sharpless JL, Rado K, et al. Evidence that GnRH decreases with gonadal steroid feedback but increases with age in postmenopausal women[J]. J Clin Endocrinol Metab, 2002, 87 (5) : 2290-2296. DOI: 10. 1210/jeem. 87.5. 8508.
-
9Hall JE, Lavoie HB, Marsh EE, et al. Decrease in gonadotropin- releasing hormone (GnRH) pulse frequency with aging in postmenopausal women[ J]. J Clin Endocrinol Metab, 2000, 85 (5): 1794-1800. DOI: lO. 1210/jcem. 85.5.6612.
-
10Maffucci JA, Gore AC. Hypothalamic neural systems controlling the female reproductive life cycle gonadotropin-releasing hormone, glutamate, and GABA[ J]. Int Rev Cell Mol Biol, 2009, 274: 69-127. DOI : 10. 1016/s1937-6448 (08) 02002-9.
-
1刘健.300例足月妊娠羊水过少分析[J].广州医药,2000,31(6):38-38. 被引量:1
-
2袁新枝,王天成,王改霞.低位产钳助产术43例临床分析[J].新医学,2001,32(10):605-606.
-
3林宏城,任东林,苏丹,彭慧.盆底功能障碍性疾病的研究进展[J].结直肠肛门外科,2010,16(2):130-132. 被引量:7
-
4黄冰清.“雄高”少女怎么办[J].大众医学,2014,0(7):51-52.
-
5陈瑛,郁琦.年龄与卵巢功能——对卵巢衰老的认识[J].中国实用妇科与产科杂志,2017,33(1):68-70. 被引量:36
-
6王世荣.腹壁瘢痕子宫内膜异位症2例[J].齐齐哈尔医学院学报,2007,28(6):672-672.
-
7张秋芳,刘平.女性生殖衰老及其对人工助孕结局的影响[J].生殖与避孕,2005,25(8):491-494. 被引量:6
-
8田秦杰.原发性闭经的病因[J].实用妇产科杂志,2014,30(5):321-323. 被引量:8
-
9古巧平.早发型重度子痫前期合并多器官功能障碍综合征临床分析[J].中国保健营养(临床医学学刊),2009,18(11):71-73.
-
10周子安,周大海.绝经综合征[J].自我药疗,2012(5):83-84.