脑动脉瘤介入治疗策略及危险因素研究

Study on the treatment strategy and risk factor intervention of cerebral aneurysm

目的探讨脑动脉瘤介入治疗的策略及危险因素。方法将46例行开颅夹闭术患者设置为对照组,将29例行脑动脉瘤介入术的患者设置为研究组,比较分析两组患者的疗效;对脑动脉瘤介入术的危险因素进行Logistic分析。结果研究组患者的疗效与对照组相比差异显著,P﹤0.05;单因素分析显示,动脉粥样硬化、糖尿病、动脉瘤大小、血管痉挛为动脉瘤破裂的影响因素,吸烟史、动脉瘤大小、血管痉挛、瘤颈特征为血栓形成的影响因素P值均﹤0.05;多因素Logistic回归分析显示动脉粥样硬化和血管痉挛为动脉瘤破裂的独立危险因素,瘤颈特征为血栓形成的唯一独立危险因素,P﹤0.05。结论脑动脉瘤介入术的疗效优于开颅夹闭术;动脉粥样硬化、血管痉挛和瘤颈特征是影响动脉瘤介入术并发症的主要危险因素。

Objective To investigate the treatment strategy and risk factor intervention of cerebral aneurysm. Methods Set the 46 patients undergoing craniotomy clipping of cerebral vascular to control group, the 29 patients with cerebral aneurysm intervention were set as the study group. Then, comparative analysis the efficacy of the two groups of patients and the risk factors for cerebral aneurysm intervention with Logistic analysis. Results Significant differences in the efficacy of the study group and the control group of patients, P﹤0.05. Univariate analysis showed that, atherosclerosis diabetes, aneurysm size and vascular spasm were the influence factors for aneurysm rupture, smoking history, aneurysm size, vascular spasm and neck tumors characterized were the influence factors for thrombosis, P﹤0.05. Logistic regression analysis showed that atherosclerosis and vascular spasm were the independent risk factors for aneurysm rupture, the neck tumor characterized was the only independent risk factor for thrombosis, P﹤0.05. Conclusion The efficacy of cerebral aneurysm intervention was better than craniotomy clipping of cerebral vascular. Atherosclerosis, vasospasm and neck tumor characteristics were the main risk factors for aneurysm intervention complications.