血浆同型半胱氨酸水平与冠状动脉慢血流的相关性分析

Elevated level of plasma homocysteine in patients with slow coronary flow

目的研究血浆同型半胱氨酸（Hcy）水平与冠状动脉慢血流现象（CSFP）的相关性。方法选择2010.8月-2014.12月于我院疑诊冠心病行冠状动脉造影检查而未见冠脉确切狭窄者72例。通过校正TIMI血流计帧法（c T-FC）计算各支冠状动脉的TIMI帧数。冠状动脉平均帧数大于27帧定义为CSF。将上述患者分为研究组（CSF组）28例,其余44例为对照组。测定俩组间血浆Hcy水平,同时对CSF现象的多项危险因素进行logistic回归分析。结果研究组血浆Hcy水平明显高于对照组,有统计学意义（12.55±2.6μmol/l;8.29±1.25μmol/l,P﹤0.001）。Logistic回归显示Hcy是影响CSF的危险因素（OR=1.287,P﹤0.01）。结论血浆Hcy水平与CSFP存在正相关,其是CSFP形成的危险因素,参与了CSFP的发生。

Objective To study the plasma homocysteine（Hcy） levels with coronary slow flow phenomenon（CSFP） relevance. Methods 2010.8 months-2014.12 months in our hospital for suspected coronary heart disease underwent coronary angiography and coronary artery stenosis in 72 cases no definite. Through the corrected TIMI frame blood flow meter method（c T-FC） calculation of the coronary artery TIMI frame count. Coronary artery average frames is greater than 27 frames defined as CSF. These patients can be divided into research group（CSF） 28 cases, the rest of the 44 cases as control group. The determination of plasma Hcy levels between the two groups, at the same time a number of risk factors on the phenomenon of CSF logistic regression analysis. Results the plasma Hcy levels are significantly higher than the control group, the group was statistically significant（12.55±2.6μmol/l, 8.29±1.25μmol/l, P﹤0.001）. Logistic regression showed that Hcy is a risk factor for CSF（OR=1.287, P﹤0.01）. Conclusion plasma Hcy levels is positively correlated with CSFP, the formation of CSFP risk factors involved in the occurrence of CSFP.