卡前列素氨丁三醇治疗产后子宫收缩乏力出血的疗效观察

Observation on Efficacy of Carboprost Tromethamine in Treatment of Postpartum Hemorrhage Caused by Uterine Inertia

目的:探讨卡前列素氨丁三醇治疗产后子宫收缩乏力出血的临床效果。方法:选取2014年2月—2015年6月产后出血需治疗的患者146例,按随机数字表法分为观察组和对照组,每组各73例。对照组患者给予常规治疗,观察组在对照组治疗的基础上加用卡前列素氨丁三醇,比较2组治疗后的疗效、止血时间、产后2和24 h出血量、血红蛋白下降范围以及不良反应发生情况。结果:观察组患者的总有效率为95.9%(70/73),明显高于对照组的72.6%(50/73),差异有统计学意义(P<0.05)。观察组患者止血时间明显短于对照组,产后2和24 h出血量明显少于对照组,差异均有统计学意义(P<0.05);观察组患者血红蛋白下降幅度明显低于对照组,差异有统计学意义(P<0.05);2组患者均未见明显不良反应。结论:卡前列素氨丁三醇治疗产后子宫收缩乏力出血的临床效果较好,且安全性较高,值得临床推广。

OBJECTIVE： To probe into the clinical effects of carboprost tromethamine in treatment of postpartum hemorrhage caused by uterine inertia. METHODS： 146 patients with postpartum hemorrhage caused by uterine inertiaadmitted from Feb. 2014 to Jun. 2015 were selected to be divided into observation group and control group via the random number table,with 73 cases in each. The control group were given conventional therapy,while the observation group additionally received carboprost tromethamine based on the control group. The efficacy,hemostatic time,bleeding volume of postpartum 2h and 24 h,falling range of hemoglobin and occurrence of adverse drug reactions were compared between two groups after treatment. RESULTS： The total effective rate of observation group was 95. 9%（ 70 /73）,significantly higher than that of control group [72. 6%（ 50 /73） ],with statistically significant difference（ P〈0. 05）. The hemostatic time of observation group was shorter than that of control group,and the bleeding volume of postpartum 2 h and 24 h was less than that of control group,with statistically significant difference（ P〈0. 05）; and the falling range of hemoglobin of observation group was lower than that of control group,with statistically significant difference（ P〈0. 05）. There were no obvious adverse drug reactions in two groups. CONCLUSIONS： The clinical efficacy of carboprost tromethamine in treatment of postpartum hemorrhage caused by uterine inertia is remarkable,which has high safety and is worthy of clinical application and promotion.