摘要
目的:探讨血必净注射液联合乌司他丁治疗急性百草枯中毒的疗效,为临床治疗急性百草枯中毒提供参考。方法:选择2012年1月—2016年1月收治的90例急性百草枯中毒患者,按照抽签法将患者分为观察组和对照组,每组各45例。对照组患者给予清洁灌肠、大量补液、利尿、保护脏器功能、实施血液灌流等常规治疗,观察组在对照组治疗的基础上,给予血必净注射液联合乌司他丁治疗,观察2组患者死亡、肺纤维化及多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS)发生情况,并对治疗第5日时各血气指标进行分析。结果:观察组患者死亡、肺纤维化及MODS发生率均明显低于对照组,差异有统计学意义(P<0.05);观察组患者氧分压、二氧化碳分压、HCO^-_3均明显优于对照组,差异有统计学意义(P<0.05)。结论:急血必净注射液联合乌司他丁治疗急性百草枯中毒,可改善患者脏器功能,降低死亡率,减少肺纤维化及MODS的发生,是相对有效的治疗方案。
OBJECTIVE： To probe into the efficacy of Xuebijing injections combined with ulinastatin in treatment of acute paraquat poisoning,so as to provide reference for the clinical treatment of acute paraquat poisoning. METHODS：90 patients with acute paraquat poisoning admitted from Jan. 2012 to Jan. 2016 were selected to be divided into observation group and control group via the drawing of lots,with 45 cases in each. The control group were treated with conventional treatment as cleansing enema,plentiful fluid infusion,diuretic,organ protection and hemoperfusion; while the observation group additionally received Xuebijing injections combined with ulinastatin based on the control group.The occurrence of death,pulmonary fibrosis and multiple organ dysfunction syndrome（ MODS） in two groups were observed. And various blood- gas parameters after treatment of five days were analyzed. RESULTS： The death rate,incidence of pulmonary fibrosis and MODS of observation group were significantly lower than that of control group,with statistical significance（ P〈0. 05）. The partial pressure oxygen and carbon dioxide,HCO-3 in observation group were significantly better than that of control group,with statistical significance（ P〈0. 05）. CONCLUSIONS： Xuebijing injections combined with ulinastatin in treatment of acute paraquat poisoning can improve the patients＇ organ function,reduce the death rate and incidence of pulmonary fibrosis and MODS. It is relatively effective treatment scheme.
出处
《中国医院用药评价与分析》
2016年第7期931-933,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
