培美曲塞与奥沙利铂联合治疗晚期结肠癌的疗效观察

Effects Observation on Pemetrexed Combined with Oxaliplatin in Treatment of Advanced Colorectal Cancer

目的:探讨培美曲塞与奥沙利铂联合治疗晚期结肠癌的临床疗效。方法:选取2013年10月—2014年1月沈阳二四二医院收治的晚期结肠癌患者100例,以随机数字表法分为观察组和对照组各50例。对照组患者给予奥沙利铂与氟尿嘧啶联合治疗,观察组患者则给予培美曲塞与奥沙利铂联合治疗。比较2组患者的临床治疗效果。结果:治疗后,观察组患者的总缓解率显著高于对照组,肿瘤内分泌指标及不良情绪均显著优于对照组,差异均有统计学意义(P<0.05)。随访1年,观察组患者生存率为10%(5/50),对照组为2%(1/50),差异有统计学意义(P<0.05)。结论:采用培美曲塞与奥沙利铂联合治疗晚期结肠癌,疗效良好,值得推广。

OBJECTIVE： To probe into the clinical efficacy of pemetrexed combined with oxaliplatin in treatment of advanced colorectal cancer. METHODS： 100 patients with advanced colorectal cancer admitted into 242 Hospital of Shenyang from Oct. 2013 to Jan. 2014 were selected to be divided into observation group and control group via the random number table,with 50 cases in each. The control group were treated with oxaliplatin combined with fluorouracil,while the observation group received pemetrexed combined with oxaliplatin. The clinical treatment effects of two groups were observed and compared. RESULTS： After treatment,the remission rate of observation group was significantly higher than that of control group,the tumor endocrine indicators and unhealthy emotions of observation group was significantly better than that of control group,with statistically significant difference（ P〈0. 05）. After follow- up of one year,the survival rate of observation group was 10%（ 5 /50）,and control group was 2%（ 1 /50）,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The efficacy of pemetrexed combined with oxaliplatin in treatment of advanced colorectal cancer is remarkable,which is worthy of clinical application and promotion.