痰液标本来源金黄色葡萄球菌的耐药性及感染分布分析

Infection distribution and resistance of staphylococcus aureus from sputum samples

目的探讨痰液标本来源金黄色葡萄球菌（SA）的耐药性及感染分布。方法 126株痰液标本来源SA收集于2013年1月至2016年1月。运用全自动微生物分析仪鉴定细菌。采用K-B法检测药物敏感性。统计SA的标本类型、感染患者的年龄,采用χ~2检验分析数据。结果 MRSA占73.02%（92株）,红霉素的耐药率最高（76.19%）,MRSA对头孢西丁、阿米卡星和环丙沙星等耐药率明显高于MSSA（P〈0.05）。来源于呼吸内科和ICU的SA分别占27.78%（35株）和17.46%（22株）,MRSA在ICU的构成比为86.36%。SA来源于≥60岁患者的构成比为69.84%。结论痰液标本来源SA的耐药形势不容乐观,MRSA的耐药形势更加严峻,SA来源于呼吸内科和≥60岁患者最为常见,而MRSA在ICU的构成比最高。

Objective To investigate the infection distribution and resistance of staphylococcus aureus（SA） from sputum.Methods A total of 126 strains of SA were collected from January 2013 to January 2016.The bacteria identification and detection of drug sensitivity were respectively performed by automated microbiology analyzer and K-B disc diffusion method.The type of specimen,the age of infection patients were statistically analyzed by using Chi-square test.Results 73.02% of the specimen（92 strains） were methicillin resistant staphylococcus aureus（MRSA）.The rate resistance to erythrocin was the highest（76.19%）.The resistanceratio of MRSA to Cefoxitin,Amikacin and Ciprofloxacin were significantly higher than the methicillin sensitive staphylococcus aureus（MSSA）（P〈0.05）.27.78%（35 strains） and 17.46%（22 strains） SA were come from department of respiratory medicine and ICU.Constituent ratio of MRSA of ICU was 86.36%.Constituent ratio of SA of patients over 60 years old was 69.84%.Conclusions The resistance situation of SA come from sputum is serious,and the drug-resistance situation of MRSA is worse.The SA mainly came from department of respiratory medicine and patients over 60 years old.The constituent ratio of MRSA is the highest in ICU.