电针对WKY抑郁模型大鼠行为学的影响

The effect of electroacupuncture on behaviors of WKY depression models

目的:通过电针"百会"、"印堂"观察对抑郁模型大鼠的行为学影响。方法:27只雄性WKY大鼠被随机分至电针组、假针组和模型组;雄性Wistar大鼠9只分为正常组。电针组取穴为"百会"、"印堂",假针组给予安慰治疗,模型组和正常组常规饲养,21d后测定各组大鼠体重、糖水消耗量(SPT)、强迫游泳实验(FST)及旷场实验(OFT)的改变。结果:电针组体重明显增加,高于假针组(P<0.05),正常组体重明显高于模型组(P<0.01);电针组蔗糖水喜好率明显高于假针组(P<0.05),正常组蔗糖水喜好率高于模型组(P<0.05);强迫游泳试验中电针组和正常组不动时间少于假针组和模型组(P<0.05);旷场实验中电针组和正常组水平运动和垂直攀爬得分高于假针组和模型组(P<0.05)。结论:电针对WKY抑郁模型大鼠的行为学核心症状有明显的改善作用。

Objective ：To observe the behavior of depression model rats and antidepressant effects of “Baihui”（GV20） and “Yintang”（EA-HN3） .Methods ：27 male WKY rats were randomly divided into EA group ,sham EA group and model group ;9male Wistar rats were as normal group .EA group and sham EA group were in tervened daily ,the mod-el group and normal group were conventional breeding .Body weight ,sucrose preference test（SPT ） ,open field test（OFT ） and forced swimming test （FST ） were measured in rats after 21d to evaluate antidepressant-like effect of the electroacu-puncture treatment .Results ：After treatment ,body weight of the EA group increased significantly than sham EA group （P〈 0 .05） .The weight of normal group was significantly greater than the model group （P 〈 0 .01） ;sucrose preference rate was significantly higher in EA group than sham EA group （P〈 0 .05） ,sucrose preference rate was significantly high-er in normal group than model group（P〈 0 .05） ;in forced swimming test ,the immobility time in the EA group and the normal group was less than sham EA group and model group （P 〈 0 .05） ;in open field test ,horizontal movement and vertical climbing scoresare higher in the EA group and normal group than sham EA group and model group （P〈 0 .05） . Conclusion ：The depression-like behaviors of WKY depression models were improved by electroacupuncture treatment .