加巴喷丁联合神经营养药治疗带状疱疹后神经痛的临床观察

Clinical observation of gabapentin combined with neurotrophic drug in the treatment of post-herpetic neuralgia

目的分析加巴喷丁联合神经营养药治疗带状疱疹后神经痛的临床疗效。方法 65例带状疱疹后神经痛患者,随机分为观察组(33例)及对照组(32例)。对照组给予神经营养药物甲钴胺治疗,观察组在此基础上联合加巴喷丁治疗。对比治疗效果。结果观察组治疗后20例完全缓解,10例显著缓解,3例轻度缓解,0例无效;对照组治疗后8例完全缓解,11例显著缓解,9例轻度缓解,4例无效。两组对比差异具有统计学意义(P<0.05)。观察组疼痛分数、疼痛问卷简表(SF-MPQ)总分、感觉评分、情感评分低于对照组,影响睡眠、影响生活例数少于对照组(P<0.05)。结论带状疱疹后神经痛患者采用加巴喷丁联合神经营养药治疗,效果良好,对疼痛缓解具有一定的效果。

Objective To analyze clinical effect by gabapentin combined with neurotrophic drug in the treatment of post-herpetic neuralgia. Methods A total of 65 patients with post-herpetic neuralgia were randomly divided into observation group （33 cases） and control group （32 cases）. The control group received mecobalamine as neurotrophic drug treatment, and the observation group received additional gabapentin. Curative effects were compared between the two groups. Results After treatment there were 20 complete remission cases, 10 excellent remission cases, 3 mild remission cases and 0 ineffective case in the observation group. In the control group there were 8 complete remission cases, 11 excellent remission cases, 9 mild remission cases and 4 ineffective cases. The difference between the two groups had statistical significance （P〈0.05）. The observation group had all lower pain score, total short-form McGill pain questionnaire （SF-MPQ） score, sensory score, emotional score, and less cases with affected sleep or life than the control group （P〈0.05）. Conclusion Combination of gabapentin and neurotrophic drug shows precise effect in treating post-herpetic neuralgia, and this method contains certain effect for pain relief.