妊娠期糖尿病胰岛素的治疗特点及对母婴结局的影响

Characteristics of insulin therapy in gestational diabetes mellitus and its effect on maternal and neonatal outcomes

目的探究妊娠期糖尿病患者应用胰岛素治疗的特点及对母婴结局的影响。方法回顾性分析2014年1月～2015年9月在我院住院分娩的妊娠期糖尿病患者249例的临床资料，将其分为试验组58例和对照组191例。试验组联合采用胰岛素治疗，对照组采用饮食治疗，并对比两纽的母婴结局。结果随着孕周增加，胰岛素使用量也不断增大，且不同患者间差异大。两组患者母婴结局对比，差异无统计学意义（P〉0．05）；试验组相比于对照组其孕妇酮症及胎膜早破的发生率显著降低，差异有统计学意义（P〈0．05）。结论对妊娠期糖尿病患者应根据其具体情况使用胰岛素进行治疗，要严格个体化，胰岛素的正确使用能有效的改善患者的血糖状况。

Objective To investigate the gestation period diabetes patients with insulin treatment and the effects on maternal and neonatal outcomes.Methods The clinical data of 249 cases of gestational diabetes mellitus admitted in our hospital from January 2014 to September 2015 were retrospectively analyzed.The clinical data of 58 cases were divided into experimental group and control group,191 cases were divided into two groups.The experimental group was treated with insulin therapy, the control group was treated with diet, and the maternal and infant outcomes of the two groups were compared.Results With the increase of gestational age,the use of insulin is also increasing,and the difference between patients is large.Two groups of patients with pregnancy outcome comparison,the difference was not statistically significant （P〉0.05）.In the experimental group than in control group,the pregnant women of ketosis and fetal membranes early break occurred was significantly lower compared,the difference is statistically significant （P〈0.05）.Conclusion The treatment of patients with gestational diabetes mellitus should be based on the specific circumstances of the use of insulin,to be strictly individualized,the correct use of insulin can effectively improve the patient＇s blood glucose status.