硫酸镁联合拉贝洛尔治疗重度妊娠高血压综合征的疗效和安全性研究

Study on the efficacy and safety of Magnesium Sulfate joint labetalol in the treatment of severe pregnancy induced hypertension syndrome

目的探讨硫酸镁联合拉贝洛尔治疗重度妊娠高血压综合征（PIH）的疗效。方法选择我院2014年1月-2015年10月收治的重度PIH孕妇172例，将其随机分为对照组和治疗组，各86例。对照组给予硫酸镁常规解痉降压治疗，观察组在硫酸镁基础上应用拉贝洛尔治疗。比较两组患者的疗效。结果治疗后，观察组血压控制有效率明显优于对照组，差异有统计学意义（P〈0．05）；两组患者在宫颈裂伤、子宫过度刺激、产后出血等主要并发症发生率比较，差异有统计学意义（P〈0．05）。结论硫酸镁联合拉贝洛尔治疗重度PIH的疗效确切，并发症发生率低，能有效降低患者平均动脉血压，改善母婴结局，具有广阔的临床应用前景。

Objective To study the joint labetalol magnesium sulfate in the treatment of severe pregnancy- induced hypertension syndrome （PIH）.Methods Our hospital from January 2014 to October 2015 were 172 cases of severe PIH pregnant women were randomly divided into control group and treatment group 86 examples,the control group given conventional spasmolysis step-down magnesium sulfate,observation group based on magnesium sulfate,the application of labetalol injection in 5% glucose injection intravenous drip.Results Two groups of patients after treatment of blood pressure control efficient observation group was better than control group（P〈0.05）;Complication rates,two groups of patients in cervical laceration,uterine overstimulation,the incidence of postpartum hemorrhage were significant difference （P 〉 0.05）.Conclusion Magnesium sulfate combined labetalol treatment of severe PIH effect is exact,complication rates were low, can effectively reduce the patients with mean arterial blood pressure,improve and outcomes,has wide prospect of clinical application.