乳腺癌转移抑制基因1抑制肿瘤转移的作用机制

Mechanism of breast cancer metastasis suppressor gene 1 inhibiting tumor metastasis

乳腺癌转移抑制基因1（BRMS1）在多种恶性肿瘤细胞中表达降低或缺失，具有明显降低癌细胞侵袭和转移的作用。BRMS1基因通过磷酸肌醇信号及核转录因子-κB（NF-κB）信号通路等调节基因转录和蛋白翻译，还可与mSin3-组蛋白去乙酰化酶（HDAC）复合体、雌激素受体等蛋白相互作用、修复细胞间隙通讯等途径抑制肿瘤细胞的侵袭及转移。BRMS1基因将可能成为有效抑制肿瘤转移基因治疗的新靶点。

Breast cancer metastasis suppressor gene 1（BRMS1） significantly reduces the invasion and metastasis of cancer cells. BRMS1 gene expression is decreased or deleted in the cells of various malignant tumors. BRMS1 gene can inhibit tumor cells invasion and metastasis by means of regulating gene transcription and protein translation by phosphoinositide signaling and nuclear factor-κB （NF-κB） signaling pathways, repairing intercellular communication and interacting with the mSin3histone deacetylase （HDAC） complex, estrogen receptor and other proteins. BRMS1 gene may be a new target for the gene treatment of tumor metastasis.