摘要
目的:探讨血清脂蛋白a[Lp(a)]水平与冠状动脉病变程度的关系。方法:318例住院患者,根据冠状动脉造影分为冠心病组(189例)和非冠心病组(129例),冠心病组又根据冠脉病变情况又分为单支病变组(93例)、双支病变组(60例)及三支病变组(36例),检测各组血清Lp(a)水平,探讨血清Lp(a)水平与冠状动脉病变的关系。结果:与非冠心病组比较,冠心病组血清Lp(a)水平明显升高[(14.89±14.71)mg/dl比(21.15±13.71)mg/dl],P<0.01;随着冠状动脉病变支数的增加,血清Lp(a)水平逐渐升高,与单支病变组比较,三支病变组血清Lp(a)水平[(21.99±13.05)mg/d比(26.94±10.32)mg/d]显著升高;与单支病变组和双支病变组比较,三支病变组Lp(a)异常率(16.2%、15.0%比25.0%)明显升高(P均<0.05);Logistic回归分析结果表明Lp(a)是冠心病的独立危险因素(OR=1.56,P=0.024)。结论:血清脂蛋白a与冠状动脉病变及其程度密切相关,可作为一项预测冠心病及其严重程度的指标。
Objective：To explore the relationship between serum level of lipoprotein a[Lp（a）]and severity of coronary artery disease.Methods：According to results of coronary angiography,a total of 318 inpatients were divided into coronary heart disease（CHD）group（n=189）and non-CHD group（n=129）.According to severity of coronary disease,CHD group was further divided into single vessel coronary disease（n=93）,double-vessel coronary disease group（n=60）and triple-vessel coronary disease group（n=36）.Serum Lp（a）level was measured in all groups,and the relationship between serum Lp（a）level and coronary artery disease was analyzed.Results：Compared with non-CHD group,there was significant rise in serum Lp（a）level[（14.89±14.71）mg/dl vs.（21.15±13.71）mg/dl]in CHD group,P〈0.01;along with number of diseased coronary vessels rose,serum Lp（a）level gradually elevated,compared with single vessel group,there was significant rise in serum Lp（a）level in triple-vessel group[（21.99±13.05）mg/d vs.（26.94±10.32）mg/d];compared with single vessel group and double-vessel group,there was significant rise in abnormal Lp（a）rate（16.2%,15.0% vs.25.0%）in triple-vessel group,P〈0.05all;Logistic regression analysis indicated that Lp（a）level was an independent risk factor for CHD（OR=1.56,P=0.024）.Conclusion：Serum lipoprotein（a）level is closely related to coronary artery disease and its severity,which can be used as an index predicting CHD and its severity.
出处
《心血管康复医学杂志》
CAS
2016年第4期371-374,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
