血清25-(OH) D3、hsCRP及NT-proBNP与慢性心衰患者心衰程度及预后的关系

Relation among serum levels of 25-(OH) D3,hsCRP,NT-proBNP and chronic heart failure severity and prognosis in patients with heart failure

目的:探究血清25羟维生素D3[25-(OH)D3]、hsCRP及NT-proBNP与慢性心衰(CHF)患者心衰程度及预后的关系。方法:选择我院CHF患者(心衰组,136例),其中NYHAⅡ级44例、Ⅲ级46例、Ⅳ级46例,另选择同期在我院健康体检正常者为健康对照组(120例)。检测各组研究对象血清中的25-(OH)D3、hsCRP及NT-proBNP水平,并进行比较。结果:与健康对照组比较,心衰组治疗前hsCRP和NT-proBNP水平显著升高,25-(OH)D3水平显著降低(P均<0.01);与治疗前比较,心衰组治疗后25-(OH)D3[(13.20±4.12)μg/L比(19.10±4.01)μg/L]水平显著升高,hsCRP[(18.32±3.81)mg/L比(11.53±2.52)mg/L]和NT-proBNP[(1605.56±578.91)pg/ml比(981.43±231.46)pg/ml]水平显著降低(P均<0.01);心衰组治疗前及治疗后,随着心衰等级的增加,25-(OH)D3水平均显著降低,hsCRP和NT-proBNP水平均显著升高(P均<0.01)。与未发生心脏事件组比较,发生心脏事件组患者血清中的25-(OH)D3[(14.52±2.10)μg/L比(10.04±2.19)μg/L]水平显著降低,hsCRP[(16.02±2.78)mg/L比(19.50±2.34)mg/L]和NT-proBNP[(1359.05±252.56)pg/ml比(1699.13±346.67)pg/ml]水平显著升高(P均<0.01)。结论:血清25羟维生素D3、hsCRP和NTproBNP水平对心衰患者心衰程度和预后的评价具有十分重要的意义。

Objective：To explore relation among serum levels of 25-hydroxyl vitamin D3 [25-（OH）D3],hsCRP,NT-proBNP and chronic heart failure（CHF）severity and prognosis in CHF patients.Methods：A total of 136 CHF patients were enrolled as CHF group,including 44 cases of NYHA class II,46 cases of class III and 46 cases of class IV.Another 120 healthy subjects undergoing physical examinations in our hospital during the same period were enrolled as healthy control group.Serum levels of 25-（OH）D3,hsCRP and NT-proBNP were measured and compared between two groups.Results：Compared with healthy control group,before treatment,there were significant rise in serum levels of hsCRP and NT-proBNP,and significant reduction in serum 25-（OH）D3level in CHF group,P〈0.01all;compared with before treatment,after treatment there was significant rise in serum 25-（OH）D3level[（13.20±4.12）μg/L vs.（19.10±4.01）μg/L],and significant reductions in serum levels of hsCRP[（18.32±3.81）mg/L vs.（11.53±2.52）mg/L]and NT-proBNP [（1605.56±578.91）pg/ml vs.（981.43±231.46）pg/ml]in CHF group,P〈0.01all;in CHF group,serum 25-（OH）D3level significantly reduced,and serum levels of hsCRP and NT-proBNP significantly rose along with CHF class increased before and after treatment,P〈0.01 all.Compared with no cardiac event group,there was significant reduction in serum 25-（OH）D3level[（14.52±2.10）μg/L vs.（10.04±2.19）μg/L],and significant rise in serum levels of hsCRP[（16.02±2.78）mg/L vs.（19.50±2.34）mg/L]and NT-proBNP[（1359.05±252.56）pg/ml vs.（1699.13±346.67）pg/ml]in cardiac event group,P〈0.01 all.Conclusion：Serum levels of 25-（OH）D3,hsCRP and NT-proBNP possess very important significance for CHF severity and prognosis assessment in CHF patients.