血管内皮祖细胞在子痫前期中的作用

The Role of Endothelial Progenitor Cells in Pre-eclampsia

子痫前期是妊娠期的严重并发症,除了提前终止妊娠外尚无有效的治疗方法,其病因及发病机制尚不清楚,但血管内皮细胞损伤是子痫前期发病的关键因素之一。血管内皮祖细胞(endothelial progenitor cells,EPCs)是血管内皮细胞的储备形式,当血管内皮细胞受损时,机体发生一系列变化以诱导募集EPCs至损伤部位,修补受损的血管内皮。但在子痫前期患者体内,损伤的血管内皮不能及时得到修复,推测子痫前期患者体内的EPCs在功能或数量上存在异常;与此同时EPCs移植可能成为治疗子痫前期的一种新方法。综述EPCs与子痫前期的关系,概括EPCs的调节因素,论述EPCs移植治疗子痫前期的可能性,以寻找预防和治疗子痫前期的新方法。

Pre-eclampsia is a serious complication of pregnancy. There is no effective treatment in addition to earlydelivery. The etiology and pathogenesis of pre -eclampsia is still unclear. Endothelial dysfunction is a characteristic ofpreeclampsia. Endothelial progenitor cells （EPCs） are stem cells which have the potential of differentiation into vascularendothelial cells. EPCs are mobilized, and then migrated to the injury position to repair the damaged vascular endothelium whenendothelial cells were damaged. But the damaged vascular endothelium of pre-eclampsic patient is not restored in time. So wespeculate that the number or function of EPCs in pre-eclampsic patient is abnormal. Meanwhile EPCs transplantation may be anew method for the treatment of pre -eclampsia. This paper detailedly explained the relationship between EPCs and pre -eclampsia, summarized the regulation of endothelial progenitor cells, and discussed the possibility of EPCs transplantation for thetreatment of pre-eclampsia, so we could find new methods of prevention and treatment of pre-eclampsia.