微小RNAs在宫颈癌中的异常表达分析

The Analysis of Dysregulated mi RNAs Involved in Cervical Cancer

微小RNAs(microRNAs,miRNAs)是现今肿瘤学研究的热点,与包括宫颈癌在内的多种恶性肿瘤的发生、发展、侵袭、转移密切有关,有关miRNAs与宫颈癌关系的研究日益增多。研究发现,有些机制能引起miRNAs异常表达,且异常表达的miRNAs通过影响重要的调节基因促进宫颈癌的发生,在宫颈肿瘤的恶性转化过程中有重要作用。本文就宫颈癌中miRNAs异常表达的可能机制及其在宫颈癌不同生物学阶段的作用进行综述。

MicroRNAs （miRNAs） have become the center of interest in oncology and are closely associated with a varietyof tumors including the occurrence, development, invasion and metastasis of cervical cancer. Great concern has been raisedregarding the correlation between cervical cancer and miRNAs. Studies demonstrated that some mechanisms could causeaberrant expressions of miRNAs. MiRNAs regulate gene expression by influencing important regulatory genes and thus areresponsible for causing cervical cancer which plays a key role in malignant transformation of cervical cancer. In this paper, thepathogenesis of miRNAs dysregulation in different stages of cervical cancer are reviewed.