小剂量索利那新治疗小儿原发性夜间遗尿症40例

Clinical Value of Small Dose of Solifenacin New Treatment for Children with Primary Nocturnal Enuresis

目的观察小剂量索利那新治疗小儿原发性夜间遗尿症的临床疗效。方法选取2012年8月—2014年8月儿科门诊收治的78例原发性夜间遗尿症患儿作为研究对象,随机分为观察组和对照组,对照组(n=38)给予排尿训练、夜间因素指导、心理调节等行为干预,观察组(n=40)在对照组行为干预的基础上加用小剂量索利那新治疗,比较两组遗尿次数及临床疗效。结果观察组夜间遗尿次数明显少于对照组(P<0.05),观察组总有效率87.5%,远高于对照组的71.1%(P<0.05),在随访复发率方面观察组同样优于对照组(P<0.05)。结论小剂量索利那新治疗小儿原发性夜间遗尿症疗效确切,配合行为干预有助于减少复发,巩固疗效。

Objective To observe the clinical value of low dose of solifenacin new treatment with children primary nocturnal enuresis. Methods From 2012 to 2014,78 patients with primary nocturnal enuresis were selected as research subjects,and randomly divided into treatment group and control group. The control group（ n = 38） received training urination,night-time factor guidance,psychological adjustment and other behavioral intervention. The treatment group（ n = 40） were treated with a small dose of solifenacin and the enuresis and clinical efficacy were compared between the two groups. Results In the treatment group,nocturnal enuresis was significantly lower than the control group（ P〈 0. 05）.The effective rate was 87. 5%,higher than the control group（ 71. 1%,P 〈0. 05）. In the follow-up visit,the recurrence rate of treatment group was lower than the control group（ P 〈0. 05）. Conclusion Small doses of solifenacin treatment for children with primary nocturnal enuresis is effective,safe and reliable. Behavioral intervention can reduce recurrence and consolidate effect.