hOT7T175蛋白在喉鳞状细胞癌中的表达及临床意义

Expression and clinical sighificance of hOT7T175 protein in laryngeal squamous cell carcinomas

目的:检测h OT7T175蛋白在喉鳞状细胞癌中的表达并探讨其临床意义。方法:收集我院病理科喉鳞状细胞癌60例及癌旁喉组织(术后病理证实)20例。应用免疫组织化学方法(IHC)检测h OT7T175蛋白在喉鳞状细胞癌和癌旁喉组织中的表达情况。结果:喉鳞状细胞癌组织和癌旁喉组织中h OT7T175蛋白阳性率分别为58.33%和95.00%,二者差异有统计学意义(P<0.05)。h OT7T175蛋白与临床分期、病理分级、淋巴结转移分级密切相关。结论:h OT7T175蛋白在喉鳞状细胞癌中的表达率显著低于癌旁喉组织;h OT7T175基因可能与喉鳞状细胞癌的发生、发展过程有关。

Objective：To investigate the expression and clinical significance of h OT7T175 protein in the laryngeal squamous cell carcinomas.Methods：The expression of h OT7T175 protein in nasopharyngeal tumor cells of 60 patients and normal tissue cells of 20 patients with nontumorous nasopharynx was detected by immunohistochemistry（ IHC）.Results：The positive rate of h OT7T175 protein in laryngeal squamous cell carcinomas was 58.33% and 95.00% in nontumorous nasopharyngeal tissue（ P〈0.05）.The expression of h OT7T175 protein correlated with clinical stage,pathological grade,lymph node metastasis in the laryngeal squamous cell carcinomas.Conclusion：h OT7T175 protein was highly expressed in nontumorous nasopharyngeal tissue and low expressed in the laryngeal squamous cell carcinomas.h OT7T175 gene may be associated with the development processes of laryngeal squamous cell carcinoma.