摘要
目的:研究腰围(WC)、腰臀比(WHR)与结直肠腺瘤、腺癌危险性之间的关系。方法:采用病例对照研究。所有结直肠腺瘤、腺癌的患者均查结肠镜活检病理证实,对照为与病例相同医院的同期就诊,结肠镜结果正常健康人群。观察组与对照组各140例,1∶1匹配。同时对腰围和臀围进行测量。采用多元Logistic回归模型对患者腰围、腰臀比与结直肠腺瘤、腺癌的比值比(OR)及其相应的95%可信区间进行估计。结果:腹型肥胖者(腰围〉85 cm)与正常腰围者(腰围≤85 cm)相比,发生结直肠腺瘤、腺癌的OR=0.98,95%CI:0.91~1.33;与正常体型者(腰臀比〈0.9)相比较,向心性肥胖者(腰臀比≥0.9)与发生结直肠腺瘤、腺癌的危险性增加有关(OR=1.16,95%CI:1.02~1.87,P〈0.05)。结论:向心性肥胖为结直肠腺瘤、腺癌的一个危险因素。
Objective:To examine the association between waist circumference( WC),waist-to-hip ratio( WHR) and colorectal adenomas,adenocarcinoma.Methods:A hospital-based case control study was conducted.Cases( n = 140) in observation group were confirmed adenoma or adenocarcinoma,and controls( n = 140) were normal healthy people.Results:The difference between abdominal obesity males( WC 85cm) and those normal waist circumference( WC≤85cm) was not significant( OR = 0.98,95% CI:0.91 ~ 1.33).WHR≥0.9 was positively related to colorectal adenomas,adenocarcinoma( compared with WHR 0.9:OR = 1.16,95% CI:1.02 ~ 1.87,P〈0.05).Conclusion:Obesity,especially central obesity,is an important risk factor for colorectal adenomas,adenocarcinoma.
出处
《现代肿瘤医学》
CAS
2016年第17期2763-2765,共3页
Journal of Modern Oncology
关键词
结直肠腺瘤
结直肠腺癌
腰围
腰臀比
colorectal adenoma
colorectal adencarcinoma
waist circumference
waist-to-hip ratio