结直肠腺瘤、腺癌与腰围及腰臀比的关系

Association of waist circumference,waist-to-hip ratio with colorectal adenomas,adenocarcinoma

目的：研究腰围（WC）、腰臀比（WHR）与结直肠腺瘤、腺癌危险性之间的关系。方法：采用病例对照研究。所有结直肠腺瘤、腺癌的患者均查结肠镜活检病理证实,对照为与病例相同医院的同期就诊,结肠镜结果正常健康人群。观察组与对照组各140例,1∶1匹配。同时对腰围和臀围进行测量。采用多元Logistic回归模型对患者腰围、腰臀比与结直肠腺瘤、腺癌的比值比（OR）及其相应的95%可信区间进行估计。结果：腹型肥胖者（腰围〉85 cm）与正常腰围者（腰围≤85 cm）相比,发生结直肠腺瘤、腺癌的OR=0.98,95%CI：0.91~1.33;与正常体型者（腰臀比〈0.9）相比较,向心性肥胖者（腰臀比≥0.9）与发生结直肠腺瘤、腺癌的危险性增加有关（OR=1.16,95%CI：1.02~1.87,P〈0.05）。结论：向心性肥胖为结直肠腺瘤、腺癌的一个危险因素。

Objective：To examine the association between waist circumference（ WC）,waist-to-hip ratio（ WHR） and colorectal adenomas,adenocarcinoma.Methods：A hospital-based case control study was conducted.Cases（ n = 140） in observation group were confirmed adenoma or adenocarcinoma,and controls（ n = 140） were normal healthy people.Results：The difference between abdominal obesity males（ WC 85cm） and those normal waist circumference（ WC≤85cm） was not significant（ OR = 0.98,95% CI：0.91 ~ 1.33）.WHR≥0.9 was positively related to colorectal adenomas,adenocarcinoma（ compared with WHR 0.9：OR = 1.16,95% CI：1.02 ~ 1.87,P〈0.05）.Conclusion：Obesity,especially central obesity,is an important risk factor for colorectal adenomas,adenocarcinoma.