米力农结合艾司洛尔治疗危重型手足口病的应用效果

Application effect of milrinone combined with esmolol in the treatment of critical type foot and mouth disease

目的研究危重型手足口病采取米力农结合艾司洛尔共同治疗的应用效果。方法选取2014年3月至2015年3月接收的96例危重型手足口病的患儿,采取数字随机法分为实验组和对照组。对照组的患儿采取米力农进行治疗,实验组在此基础之上采取艾司洛尔治疗。对两组临床各项指标[HR、收缩压(SBP)、心排出量(CO)、左心室射血分数(LVEF)、血浆脑利钠肽(BNP)以及去甲肾上腺素(NE)]变化情况和治疗效果给予对比分析。结果治疗前,两组患儿的各项观察指标差异无统计学意义(P>0.05);治疗1 h后,实验组患儿的各项指标改善情况显著优于对照组(P<0.05);治疗48 h后,实验组患儿的各项观察指标改善情况显著优于对照组(P<0.05);治疗后,两组患儿均没有出现明显的不良反应。结论危重型手足口病采取米力农结合艾司洛尔共同治疗,使患儿的心脏功能得到明显改善,使患儿各项生命体征趋于稳定,具有临床推广价值。

Objective To study application effect of milrinone therapy combined with esmolol in the treatment of critical type foot and mouth disease. Methods 96 cases of type of critically ill children with foot and mouth disease from March 2014 to March 2015 received were se-lected and randomly divided into experimental and control groups. The control group was treated with milrinone,and the experimental group was treated with esmolol on the basis of milrinone. Clinical indicators[HR,systolic blood pressure（SBP）,cardiac output（CO）,left ventricular e-jection fraction（LVEF）,brain natriuretic peptide（BNP）and norepinephrine（NE）]change and treatment effect of the groups were compared and analzed. Results Before treatment,the index difference between the two groups had no statistically significant difference（ P ﹥ 0. 05）. After treatment 1 h,the indicators to improve the situation of children in the experimental group were significantly better than those in the control group （ P ﹤ 0. 05）. 48 h after treatment,various indicators in the experimental group were observed significantly better than those of control group（ P﹤ 0. 05）. After treatment,children of two groups had no obvious adverse reactions. Conclusion The application of milrinone combining esmolol in children with severe type of hand,foot and mouth disease can improve cardiac function in children with obviously,make children with each vital signs tend to be stable. Therefore,it has clinical popularization value.