老年心力衰竭患者血清Ang-(1-7)、AngⅡ水平的变化

Serum Ang-(1-7) and AngⅡ levels in elderly patients with heart failure

目的探讨老年心力衰竭患者血清中Ang-(1-7)、AngⅡ水平变化。方法入选北京友谊医院医保中心内科及心内科因失代偿心力衰竭住院的老年患者31例为心力衰竭组,对照组为性别、年龄、所患基础疾病与实验组相匹配的同期住院非心力衰竭病人。收集两组患者一般信息,采用酶联免疫吸附法测定血清Ang-(1-7)、AngⅡ的浓度。结果心力衰竭组血清Ang-(1-7)的水平(155.50±38.28 pg/ml)明显高于对照组(130.68±32.22 pg/ml),差异有统计学意义(P<0.05)。心力衰竭组患者血清AngⅡ的水平(1 346.95±236.90 pg/ml)明显高于对照组(1 190.17±122.52 pg/ml),差异有统计学意义(P<0.05)。结论 Ang-(1-7)可通过ACE2-Ang-(1-7)-MAS轴拮抗Ang II的作用,改善心肌重构,改善心功能。老年心力衰竭患者血清Ang-(1-7)水平与Ang II水平均升高,可能为机体及ACEI/ARB药物应用后的保护机制。

Objectiye To observe serum levels of Ang -（1 - 7）and AngⅡin Elderly Patients with Heart Failure. Methods A total number of 31 elderly patients with heart failure and 31 patients without heart failure as control group were enrolled in this study. The general data, laboratory data and UCG parameters were collected. The concentration of Ang -（1 - 7）and AngⅡ was detected by using ELISA. Results The serum concentration of Ang -（1 - 7）was significantly higher in patients with heart failure than those in control group（155. 50 ± 38. 28 pg/ ml vs. 130. 68 ± 32. 22 pg/ ml,P 〈 0. 05）. The level of serum AngⅡwas significantly higher in patients with heart failure than those in control group;（1 346. 95 ± 236. 90 pg/ ml vs. 1 190. 17 ± 122. 52 pg/ ml,P 〈 0. 05）. Conclusion Both serum Ang -（1 - 7）and Ang II levels were increased in elderly patients with heart failures,which indicate RAS system activation in heart failure. The elevation of serum Ang -（1 - 7）level might be protection caused by autoregulation and ACEI / ARB drugs using.