焦虑抑郁状态对老年高血压患者动态血压和血压变异性的影响研究

Study on the impact of anxiety and depression on variability of blood pressure in elderly hypertensive patients

目的探讨抑郁焦虑状态对老年高血压患者动态血压和血压变异性的影响。方法选择老年高血压患者共124例,分为研究组(高血压合并焦虑抑郁患者共53例)与对照组(未合并焦虑抑郁的患者共71例),比较两组的动态血压和血压变异性。结果研究组昼间收缩压、昼间脉压和24 h脉压显著高于对照组(P<0.05),夜间收缩压、舒张压及脉压与对照组无统计学差异,24 h收缩压、24 h舒张压与对照组无统计学差异。研究组24 h收缩压变异性显著低于对照组,24 h舒张压变异性与对照组无统计学差异,非杓型动态血压节律病人占比明显高于对照组,差异均有显著性(P<0.05)。结论焦虑抑郁情绪会导致原发性高血压患者动态血压水平与非杓型血压的发生率增高。

Objectiye To explore the impact of anxiety and depression on variability of blood pressure in elderly hypertensive patients. Methods A total of 124 elderly hypertensive patients were collected and they were divided into study group（anxiety and depression in patients with hypertension,53 cases）and control group（no consolidated anxiety and depression in patients,71 cases）. Changes of ambulatory blood pres-sure were observed and compared between these two groups. Results The daytime systolic blood pressure,pulse pressure and 24h daytime pulse pressure in patients of study group were significantly higher（ P 〈 0. 05）than those of patients in control group,meanwhile nighttime systolic blood pressure,diastolic blood pressure and pulse pressure were significantly different with those of control group,and the difference in 24 h SBP and 24 h diastolic blood pressure was not significant in comparison with those of control group. In study group,variability in 24 h SBP was significantly lower than that of control group,and there was no significant difference in variability of 24 h diastolic blood pressure in control group. The propor-tion of patients with non - dipper rhythm of ambulatory blood pressure was significantly higher than that of patients in control group（ P 〈 0. 05）. Conclusion Anxiety and depression can lead to the increase of dynamic blood pressure and the incidence of non - dipper blood pressure in pa-tients with essential hypertension.