顺铂化疗联合氟尿嘧啶对食管癌患者血清CEA水平的影响

Effects of Cisplatin Combined with Fluorouracil on the Serum Levels of CEA in Patients with Esophageal Cancer

目的:探讨顺铂联合氟尿嘧啶化疗对食管癌患者血清癌胚抗原(CEA)及角蛋白19片段(Cyfa21-1)浓度的影响及其临床疗效。方法:选择我院收治的食管癌患者60例,随机分为实验组和对照组,每组30例。对照组患者给予氟尿嘧啶,实验组患者在对照组的基础上联合使用顺铂。比较治疗前后两组患者血清CEA及Cyfa21-1浓度的变化,应用KPS评分表评价两组患者治疗前后的生活质量,并对比分析两组患者治疗后的临床疗效及不良反应。结果:与治疗前相比,两组患者血清CEA及Cyfa21-1浓度均较低,KPS评分较高(P<0.05);与对照组相比,实验组患者血清CEA及Cyfa21-1浓度较低,KPS评分较高(P<0.05);与对照组相比,实验组患者临床有效率较高,不良反应发生率较低,差异具有统计学意义(P<0.05)。结论:顺铂联合氟尿嘧啶能较单用氟尿嘧啶有效改善食管癌患者的生活质量,提高临床疗效。

Objective： To investigate the effects of cisplatin combined with fluorouracil on the serum levels of CEA and Cyfa21-1 of patients with esophageal cancer. Methods： 60 cases of patients with esophageal cancer from our hospital were collected and randomly divided into the experimental group and control group, with 30 cases in each group. Patients in the control group were treated by fluorouracil, while patients in the experimental group were treated by cisplatin combined with fluorouracil. Then the serum CEA and Cyfra21-1 concentrations of both groups were observed and compared before and after treatment, the quality of life were evaluated by KPS scores, and the clinical efficacy were analyzed. Results： Compared with before treatment, the serum CEA and Cyfra21-1 concentrations of both groups were decreased, KPS scores were increased （P〈0.05）. Compared with the control group, the serum CEA and Cyfra21-1 concentrations of experimental group were lower, KPS score was higher （P〈0.05）; the clinical efficacy was higher （P〈0. 05）. Conclusion： Cisplatin combine with fluorouracil had better clinical efficacy in the treatment of patients with esophageal cancer than fluorouracil alone.