炎性因子、CD64与烧伤感染的相关性

Study on the correlation between neutrophil surface molecule CD64 and inflammatory factors and burn infection

目的:研究炎性因子及中性粒细胞表面分子CD64水平变化情况与烧伤感染的相关性。方法:选取2010年3月至2015年10月我院收治46例烧伤感染患者为研究对象标记为观察组,同时选取同期来我院体检的46例健康体检者记为对照组,两组无相关性差异。采用流式细胞仪测定两组研究对象中性粒细胞表面分子CD64、C-反应蛋白(CRP)、白细胞计数(WBC)及炎性因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子(TNF-α)]水平并进行比较。结果 :观察组中性粒细胞表面分子CD64、CRP、WBC计数及各项炎性因子水平分别均较对照组显著高(P<0.05)。结论:烧伤感染患者中性粒细胞表面分子CD64、CRP、WBC计数及炎性因子水平分别均较健康者显著高,可见中性粒细胞表面分子CD64及炎性因子与烧伤感染具有密切的相关性。

Objective To study the changes of neutrophil surface molecule CD64 and inflammatory factor levels in patients with burn infection. Methods 46 cases of patients with burn infection who were treated in the department of burn in our hospital between March 2010 and October 2015 were selected as the observation group.Meanwhile, 46 cases of healthy people who underwent physical examination in our hospital during the same period were included in the control group. The levels of neutrophil surface molecule CD64, C-reactive protein（CRP）,white blood cell count（WBC） and inflammatory factor [interleukin IL- 6（IL-6）, interleukin（IL-8）, tumor necrosis factor（TNF-α） in the two groups of subjects were determined by flow cytometry and were compared. Results In the observation group, the levels of CD64, CRP, WBC and inflammatory factors were significantly higher than those in the control group（P 0.05）. Conclusion The levels of CD64, CRP, WBC and inflammatory factors in patients with burn infection are significantly higher than those in healthy people, which indicates that neutrophil surface molecule CD64, inflammatory factors and burn infection are closely correlated.