活化诱导胞嘧啶核苷脱氨酶与白血病关系的研究进展

Research progress of relationship between activation-induced cytidine deaminase and leukemia

活化诱导胞嘧啶核苷脱氨酶（AID）作为基因的诱导突变体，将胞嘧啶脱氧核糖核苷酸脱氨转变为尿嘧啶脱氧核糖核苷酸，从而引起基因突变。相关文献报道，AID在白血病的发生、发展中起重要作用。近年，针对AID的蛋白结构及其在白血病中的作用机制、表达特点、预后意义，以及伊马替尼耐药等方面的研究取得了一定进展。笔者拟就AID的上述几个方面内容进行综述。

As an induced mutant of genes, activation-induced cytidine deaminase （AID） deaminates cytosine deoxyribonucleotide into uracil deoxyribonucleotide resulting i that AID plays an important role in the development and progression progress of AID protein structure and its mechanism, pattern of exp imatinib resistance in leukemia have been made. This article reviews lite AID n gene mutation. Literatures report of leukemia. In recent years, lots of ression, prognostic significance, and ratures on aforementioned aspects of AID.