SIAH1蛋白表达与乳腺癌新辅助化疗疗效和临床特征的相关性研究

Study of the relationship between SIAH1 protein expression and clinical features and efficacy of neoadjuvant chemotherapy in breast cancer

目的:探讨SIAH1蛋白表达与乳腺癌新辅助化疗疗效和临床特征的关系。方法:采用免疫组织化学S-P法检测123例乳腺癌患者的活检石蜡包埋组织中SIAH1蛋白的表达情况,其中56例患者接受术前新辅助化疗,分析SIAH1蛋白的表达情况与新辅助化疗疗效和临床特征的关系。结果:SIAH1蛋白的表达情况与新辅助化疗疗效以及部分临床特征相关,SIAH1蛋白高表达者的新辅助化疗有效率高于低表达者(P<0.05),SIAH1蛋白表达与组织学分级和临床分期相关(P<0.05)。结论:乳腺癌患者的SIAH1蛋白表达状况可能成为预测新辅助化疗的敏感性指标,同时可能成为乳腺癌的预后指标。

AIM： To investigate the relationship between the expression of SIAH1 protein, the effica- cy of neoadjuvant chemotherapy and the clinical characteristics in breast cancer. METHODS： Im- muno histochemical S-P method was applied to de- tect the expression of SIAH1 proteins in biopsied and paraffin embedded tissue of 123 breast cancer pa- tients, 56 of which received neoadjuvant chemother- apy to analyze the relationship between the expres- sion of SIAH1, the efficacy of neoadjuvant chemo- therapy and the clinical characteristics. RESULTS： The expression of SIAH1 protein was associated with the efficacy of neoadjuvant chemotherapy and the clinical characteristics. The efficacy of neoadjuvant chemotherapy in SIAH1 protein higher expression was significantly higher than lower expression （P 〈 0.05）, and the expression of SIAH1 protein was found related with organizational grades and clinical characteristics （ P 〈 0.05 ）. CONCLUSION ： The expression of SIAH1 protein may be a predictive marker for neoadjuvant chemotherapy as well as a prognostic marker for breast cancer.