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花生四烯酸的ω-羟化代谢途径与心脑血管疾病 被引量：7

ω-hydroxylation of arachidonic acid and cardio-cerebrovascular diseases
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摘要 花生四烯酸(arachidonic acid,AA)是人体内含量丰富的不饱和脂肪酸,其代谢产物具有多种生物活性并且参与调节多种病理生理过程。大量研究发现AA可经细胞色素P450(cytochrome P450,CYP)途径代谢,且其CYPω-羟化酶代谢产物20-羟基二十碳四烯酸(20-hydroxyeicosatetraenoic acid,20-HETE)对心脑血管疾病的发生发展有一定的影响。CYPω-羟化酶抑制剂在防治心脑血管疾病中有广泛的应用前景。本文就AAω-羟化酶的种类、表达及基因多态性、20-HETE的生理功能和AAω-羟化酶抑制剂在心脑血管疾病中的应用前景等作一综述。 Arachidonic acid is a polyunsaturat- ed fatty acid in human body, and its bioactive me- tabolites play significant roles in regulating many physiological and pathological processes. Recent studies found that arachidonic acid and its ω-hydrox- ylation metabolite, 20-hydroxyeicosatetraenoic acid （20-HETE）, contribute to the pathogenesis of many cardio-cerebrovascular diseases. Inhibiting 20-HETE synthesis with ω-hydroxylase inhibitors is considered to be the therapeutic targets for many cardio-cerebro-vascular diseases. This review summarized the ex- pression of arachidonic acid ω-hydroxylase, the effects of 20-HETE and ω-hydroxylase inhibitors in the cardio-cerebrovascular diseases.
作者 韦艺丹 许美娟 季晖
机构地区 中国药科大学药理教研室 南京中医药大学附属医院临床药理科
出处 《中国临床药理学与治疗学》 CAS CSCD 2016年第7期826-833,共8页 Chinese Journal of Clinical Pharmacology and Therapeutics
基金 国家自然科学基金项目(81202984) 江苏省"六大人才高峰"项目(WSN-054)
关键词 花生四烯酸 细胞色素P450 20-HETE 心脑血管疾病 arachidonic acid cytochrome P450 20-HETE cardio-cerebrovascular disease
分类号 R714 [医药卫生—妇产科学]
  • 相关文献

参考文献57

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二级参考文献27

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中国临床药理学与治疗学
2016年 第7期

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