新生儿血培养病原菌分布及与超敏C-反应蛋白的关系

Relationship between C-reactive protein and pathogens from neonatal blood culture

目的分析新生儿血培养阳性标本中各病原菌分布情况及与hs-CRP的相关性。方法统计分析2015年1月至2016年1月大连市妇幼保健院新生儿ICU血培养临床资料并采用CRP检测试剂盒对血培养阳性的患者进行hs-CRP的检测。结果血培养阳性结果中,凝固酶阴性葡萄球菌46株,占65.7%,肺炎克雷伯菌8株,占11.4%,大肠埃希菌5株,占7.1%,肠杆菌、鲍曼不动杆菌、洛非不动杆菌各2株,分别占2.9%,摩根摩根菌、B群链球菌、金黄色葡萄球菌、肠球菌、微球菌各1株,分别占1.4%;hs-CRP的检出量,革兰阴性菌感染组为(20.60±3.40)mg/L,革兰阳性菌感染组为(15.80±2.30)mg/L,正常对照组为(4.10±0.95)mg/L。结论新生儿血培养阳性的主要致病菌为凝固酶阴性葡萄球菌、肺炎克雷伯菌和大肠埃希菌;有细菌感染的新生儿血中hs-CRP值升高,革兰阴性菌感染hs-CRP值高于革兰阳性菌。

Objective To analyze the distribution of the pathogens isolated from neonatal blood culture,and the correlation with hs-CRP.Methods Statistical analysis was conducted on the clinical data of newborns between January 2015 and January 2016 in Dalian Maternity and Child Health Care Hospital in regard to the ICU blood culture results,and CRP test kit was used to detect the hs-CRP of the patients with positive blood culture.Results There were 46 strains of coagulase negative Staphylococcus aureus（65.7%）,8strains of Klebsiella pneumoniae（11.4%）,5strains of E.coli（7.1%）,2strains each of Enterobacteriaceae,Acinetobacter baumannii,Acinetobacter lwoffii（2.9% each）,as well as 1strain each of Morganella morganii,group B Streptococci,Staphylococcus aureus,Enterococcus, Micrococcus（1.4%each）.The level of hs-CRP was（20.60±3.40）mg/L in Gram negative bacteria infection group,（15.80±2.30）mg/L in Gram positive bacteria infection group,and（4.10±0.95）mg/L in normal control group.Conclusion The main pathogenic bacteria from positive blood culture of neonatal were coagulase negative Staphylococci aureus,Enterobacteriaceae and non-fermenter bacteria.The hs-CRP levels elevated in the newborns with bacterial infections,which were higher in newborns with Gram-negative bacteria infections than that in those with Gram positive bacteria infections.