慢性肝病幽门螺杆菌感染患者白细胞介素水平测定的临床研究

Clinical significance of interleukins levels in Helicobacter pylori infected patients with chronic liver disease

目的探讨慢性肝病幽门螺杆菌(Hp)感染患者白细胞介素-12(IL-12)、IL-18水平测定的临床意义,为临床慢性肝病诊治提供理论指导与依据。方法选择2012年10月-2015年9月于医院接受治疗的慢性乙型肝炎及肝炎肝硬化患者160例为研究对象,其中根据疾病轻重程度可分为CH-Ⅰ组(45例)、CH-Ⅱ组(58例)、CH-Ⅲ组(32例)及肝硬化组(25例),选择同期医院体检的健康人群30名为对照组,应用14 C-尿素呼气试验检测各组幽门螺杆菌(Hp)感染情况,数据采用SPSS 16.0软件进行统计分析。结果慢性肝病感染Hp患者IL-12、IL-18水平明显高于未感染Hp的患者,且随着患者肝脏炎症的加重其IL-12、IL-18值也逐渐增加,差异有统计学意义(P<0.05)。结论 Hp感染与慢性肝病有密切关系,可促进患者肝脏炎症的反应过程;慢性肝病Hp感染的患者其IL-12、IL-18水平可反应肝脏炎症的严重程度。

OBJECTIVE To investigate the clinical significance of IL-12 and IL-18 levels in Helicobacter pylori（Hp）infection in patients with chronic liver disease,so as to provide theoretical guidance and basis for clinical diagnosis and treatment of chronic liver disease.METHODS A total of 160 patients with chronic hepatitis B and liver cirrhosis in the hospital for treatment from Oct.2012 to Sep.2015 were selected,and divided into CH-Ⅰ group（45cases）,CH-Ⅱ group（58cases）,CH-Ⅲ group（32cases）and liver cirrhosis（25cases）according to the degree of severity of the disease,and another 30 cases of healthy people underwent examination during the same period were sleeted as control group.The 14 C-urea breath test was used to detect the Hp infection,and the data were analyzed by SPSS 16.0.RESULTS IL-12 and IL-18 levels of Hp infected patients with chronic liver disease were significantly higher than those of non-infected patients,and with the aggravating of liver inflammation in patients,their IL-12 and IL-18 value gradually increased（P〈0.05）.CONCLUSION Hp infection is closely related to chronic liver disease,it will promote the reaction process of liver inflammation in patients;and IL-12 and IL-18 levels in Hp infected patients with chronic liver disease may react severity of liver inflammation.