心力衰竭患者肺部感染后炎性因子的变化研究

Changes of inflammatory factors of patients with pulmonary infection and heart failure

目的研究心力衰竭患者肺部感染后炎性因子的变化,为心力衰竭肺部感染的早期诊断和治疗提供参考依据。方法选取2014年6月-2015年10月医院的52例心力衰竭肺部感染患者为A组,52例心力衰竭患者为B组,52例肺部感染患者为C组,比较3组患者血清炎性因子水平,数据采用SAS 6.0软件进行统计分析。结果 A组的炎性因子白细胞介素-6(IL-6)、转化生长因子-β(TGF-β)、肿瘤坏死因子-α(TNF-α)、降钙素原(PCT)及前列腺素E2(PGE2)血清水平分别为(15.35±1.64)pg/ml、(28.98±2.59)ng/ml、(2.76±0.32)ng/ml、(19.39±2.84)ug/L及(252.52±27.97)pg/ml,其均高于B组及C组,差异有统计学意义(P<0.05)。结论心力衰竭患者肺部感染的炎性因子呈现高表达状态,且心功能分级及肺部感染程度均对患者上述指标影响较大。

OBJECTIVE To investigate the changes of inflammatory factors of patients with pulmonary infection and heart failure,so as to provide evidence for the early diagnosis and treatment of pulmonary infection in heart failure.METHODS A total of 52 patients with pulmonary infection and heart failure in our hospital from Jun.2014 to Oct.2015 were selected as the group A,52 patients with heart failure were selected as group B,and other 52 patients with pulmonary infection were selected as group C,then serum levels of inflammatory factors of three groups were compared.The data were analyzed by SAS 6.0.RESULTS The serum levels of inflammatory factors IL-6,TGF-β,TNF-α,PCT and PGE2 of group A were（15.35±1.64）pg/ml,（28.98±2.59）ng/ml,（2.76±0.32）ng/ml,（19.39±2.84）ug/L and（252.52±27.97）pg/ml,respectively,which were all higher than those of group B and of group C,（P〈0.05）.CONCLUSIONThe inflammatory factors of patients with pulmonary infection and heart failure show high expression state,and the influence of heart function classification and pulmonary infection degree for those indexes are great.