心脏介入术后血清降钙素原及白介素-6与肺部感染的相关性研究

Correlation between PCT,IL-6,and pulmonary infection after interventional heart surgery

目的探讨血清降钙素原(PCT)与白介素-6(IL-6)与心脏介入患者术后肺部感染的相关性,为诊治心脏介入手术后肺部感染提供参考依据。方法选取2014年8月-2015年8月住院拟行心脏介入手术治疗的心脏疾病患者200例,行心脏介入手术治疗,对术前、术后3d时血清PCT、IL-6及白细胞计数(WBC)进行检测,观察术后肺部感染发生情况,数据采用SPSS 19.0软件进行统计分析。结果 200例心脏介入手术患者,术后发生肺部感染者15例,感染率为7.50%;肺部感染患者术后3d时PCT、IL-6及WBC分别为(1.35±0.22)μg/L、(18.12±4.85)mg/L、(8.67±2.02)×109/L,明显高于未感染患者,差异有统计学意义(P<0.05)。结论心脏介入手术后患者血清PCT、IL-6及WBC均有升高,术后并发肺部感染升高更为明显,术后检测PCT、IL-6及WBC对心脏介入手术后肺部感染的发生有监测作用。

OBJECTIVE To study the correlation between procalcitonin and interleukin-6and pulmonary infection after cardiac intervention,so as to provide references for clinical diagnosis and treatment of pulmonary infection after cardiac interventional therapy.METHODS A total of 200 cases of hospitalized patients with cardiac intervention in the treatment of heart disease from Aug.2014 to Aug.2015 were selected.Serum PCT,IL-6and white blood cell count（WBC）before operation and 3day after operation were detected,and the postoperative pulmonary infection were observed.The data were analyzed by SPSS 19.0.RESULTS Totally 15 cases of postoperative pulmonary infection occurred in 200 patients with interventional heart surgery,with the infection rate of 7.50%.Three days after operation,PCT,IL-6and WBC of pulmonary infection patients were（1.35±0.22）μg/L,（18.12±4.85）mg/L,and（8.67±2.02）×10^9/L,which were significantly higher than those of non pulmonary infection（P〈0.05）.CONCLUSION Serum PCT,IL-6and WBC have increased in interventional heart surgery patients,and postoperative pulmonary infections after operation were more obvious.Detection of PCT,IL-6and WBC after intervention operation have monitoring effects on the occurrence of lpulmonary infection.