慢性阻塞性肺疾病合并感染肺炎支原体的免疫状态变化研究

Immune status change research of chronic obstructive pulmonary disease with mycoplasma pneumoniae pneumonia in patients

目的探讨慢性阻塞性肺疾病(COPD)合并支原体肺炎患者免疫状态变化,为COPD合并支原体肺炎的临床诊治提供参考依据。方法选取2013年1月-2015年8月于医院诊治的单纯COPD患者(非感染组)、COPD合并支原体肺炎患者(感染组)各50例,采用免疫比浊法测定血清免疫球蛋白IgG、IgA、IgM水平,数据采用SPSS 19.0软件进行统计分析。结果感染组患者IgA、IgM分别为(2.47±0.92)(1.54±0.61)g/L,水平高于非感染组(2.21±0.87)(1.30±0.54)g/L,差异有统计学意义(P<0.05),IgG水平两组比较差异无统计学意义(P>0.05);感染组患者FVC、PEF、FEV1分别为(1.54±0.17)L、(2.95±0.27)L/s、(1.42±0.30)L,水平低于非感染组(1.63±0.20)L、(3.10±0.32)L/s、(1.55±0.25)L,差异有统计学意义(P<0.05)。结论 COPD合并支原体肺炎患者免疫状态明显存在异常,感染肺炎支原体可加重免疫功能紊乱及引起肺功能下降。

OBJECTIVE To explore chronic obstructive pulmonary disease（COPD）with mycoplasma pneumoniae pneumonia in patients with immune state changes,and to provide references for clinical diagnosis and treatment of COPD merger mycoplasma pneumonia.METHODS Simple COPD patients（no infection group）and patients with COPD merger mycoplasma pneumonia（infection group）during Jan 2013-Aug 2015 were selected,with each group of 50 cases,and immune turbidimetric method was used to determine the humoral immune indexes：immunoglobulin G（IgG）,A（IgA）,M（IgM）.The results were statistically analyzed by software SPSS19.0.RESULTS IgA and IgM of infection group were（2.21±0.87）g/L and（1.30±0.54）g/L,higher than no infection group,which were（2.47±0.92）g/L and（1.54±0.61）g/L（P〈0.05）.IgG levels were similar between the two groups with no statistical significance.FVC,PEF,FEV1 of infection group were（1.54±0.17）L,（2.95±0.27）L/s,（1.42±0.30）L,lower than those of no infection group,which were（1.63±0.20）L,（3.10±0.32）L/s,（1.55±0.25）L（P〈0.05）.CONCLUSIONCOPD merger mycoplasma pneumoniae pneumonia in patients has obvious abnormal immune state,and mycoplasma pneumoniae infection may increase immune dysfunction and lung function decline.