系统性红斑狼疮患者医院感染的危险因素与预防研究

Risk factors and prevention measures of systemic lupus erythematosus(sle)patients with hospital infection

目的分析系统性红斑狼疮患者医院感染的危险因素、临床特点及其预防措施,为其治疗提供研究资料。方法随机选择2012年1月-2015年2月医院收治的系统性红斑狼疮患者200例为研究对象,分析感染率及危险因素,数据采用SPSS 18.5软件进行统计分析。结果系统性红斑狼疮患者医院感染率为48.50%,感染发生的部位主要为呼吸道、泌尿系统、皮肤和黏膜、肠胃道、血液、软组织等部位;低C3血症、浆膜炎、低白蛋白血症、肾功能不全、免疫抑制剂的使用、住院时间、抗菌药物的使用、实验室检查指标中白细胞、血清白蛋白、C3、C-反应蛋白、血沉异常、24h尿蛋白定量等,为系统性红斑狼疮患者医院感染的相关因素,具有统计学意义(P<0.05)。结论系统性红斑狼疮患者医院感染率较高,且其危险因素较多,需要针对危险因素加强对系统性红斑狼疮医院感染的预防和控制。

OBJECTIVE To analyze the risk factors,clinic features and prevention measures of nosocomial infections in patients with systemic lupus erythematosus（sle）so as to provide research material for treatments.METHODS A total of 200 cases of patients with sle admitted from Jan.2012 to Feb.2015 were randomly chosen as study objects.The infection rates and risk factors were statistically analyzed by SPSS 18.5.RESULTS The infection rate of those patients was 48.50% and the infected sites were mainly in respiratory tract,urinary tract,skin and mucous membrane,gastrointestinal tract,blood,and soft tissue.The risk factors proved to be low C3 emia,serositis,low serum albumin emia,renal insufficiency,the use of immunosuppressants,length of hospital stay,the use of antimicrobial agents and laboratory examination indexes of WBC,C3,c-reactive protein,serum albumin,abnormal blood sedimentation,24 hurine protein quantitation,etc.and there were significant differences（P〈0.05）.CONCLUSIONThe nosocomial infection rate is high in patients with sle and the risk factors are various.Special efforts should be made to prevent and control hospital infections in patients with sle according to those risk factors.