神经外科动脉瘤术后颅内感染危险因素logistic回归分析及防范措施

Logistic regression analysis of risk factors affecting intracranial infection of aneurysm in the department of neurosurgery after operation and preventive measures

目的探讨分析影响神经外科动脉瘤术后颅内感染危险因素,并制定针对性防范措施。方法回顾性分析2011年7月-2015年10月医院129例神经外科动脉瘤手术患者临床资料,统计术后颅内感染发生率,对其感染患者进行因素分析,采用SPSS 17.0软件进行统计分析。结果 129例患者中,有14例发生颅内感染,发生率为10.85%;多因素分析结果显示,手术时间≥4h、术中动脉瘤破裂、合并糖尿病、术中脑脊液漏、术后留置引流管、术中出血量≥100ml、ICU住院时间≥1周、气管切开、术后应用激素和年龄≥60岁是手术发生感染的独立危险因素(P<0.05)。结论影响神经外科动脉瘤术后颅内感染的危险因素较多,临床上应依据具体情况制定针对性防范措施以降低颅内感染发生率。

OBJECTIVE To discuss and analyze the risk factors affecting intracranial infection of aneurysm in the department of neurosurgery after operation,and develop specific preventive measures.METHODS The clinical data of 129 cases of patients with aneurysm in the department of neurosurgery after operation were retrospective analyzed,and the incidence rate of intracranial infection of aneurysm after operation were counted,then the factors that affecting intracranial infection after operation were analyzed by single factor description and multi factor logistic regression using the statistical software SPSS 17.0.RESULTS There were 14 cases of patients occurred intracranial infection,and the incidence rate was 10.85%.The multi-variate analysis results showed that operation time more than or equal to 4h,aneurysmal rupture during operation,complicated with diabetes,cerebrospinal fluid leakage during operation,indwelling drainage tube after operation,intraoperative blood loss more than or equal to 100 ml,ICU length of stay more than or equal to 1week,incision of trachea,application of hormone after operation and age more than or equal to 60 years old were independent risk factors of the infections（P〈0.05）.CONCLUSIONThere are so many factors affecting intracranial infection of aneurysm in the department of neurosurgery after operation,and specific preventive measures should be developed according to specific circumstances for the decreasing of incidence rate of intracranial infection.